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10.1586/14737159.2016.1139455

http://scihub22266oqcxt.onion/10.1586/14737159.2016.1139455
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C4965161!4965161!26760313
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suck abstract from ncbi


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pmid26760313      Expert+Rev+Mol+Diagn 2016 ; 16 (4): 387-93
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  • Profile of the Pleximmune blood test for transplant rejection risk prediction #MMPMID26760313
  • Sindhi R; Ashokkumar C; Higgs BW; Levy S; Soltys K; Bond G; Mazariegos G; Ranganathan S; Zeevi A
  • Expert Rev Mol Diagn 2016[]; 16 (4): 387-93 PMID26760313show ga
  • The Pleximmune? test (Plexision Inc., Pittsburgh, PA, USA) is the first cell-based test approved by the US FDA, which predicts acute cellular rejection in children with liver- or intestine transplantation. The test addresses an unmet need to improve management of immunosuppression, which incurs greater risks of opportunistic infections and Epstein?Barr virus-induced malignancy during childhood. High-dose immunosuppression and recurrent rejection after intestine transplantation also result in a 5-year graft loss rate of up to 50%. Such outcomes seem increasingly unacceptable because children can experience rejection-free survival with reduced immunosuppression. Pleximmune test sensitivity and specificity for predicting acute cellular rejection is 84% and 81% respectively in training set?validation set testing of 214 children. Among existing gold standards, the biopsy detects but cannot predict rejection. Anti-donor antibodies, which presage antibody-mediated injury, reflect late-stage allosensitization as a downstream effect of engagement between recipient and donor cells. Therefore, durable graft and patient outcomes also require an accurate management of cellular immune responses in clinical practice.
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