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10.1002/smll.201502119 http://scihub22266oqcxt.onion/10.1002/smll.201502119 C4964272!4964272!26780591     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Small 2016 ; 12 (16): 2173-85 Nephropedia Template TP {{tp|p=26780591|t=2016. Protocells: Modular mesoporous silica nanoparticle-supported lipid bilayers for drug delivery |pdf=|usr=}}{{26780591}} gab.com Text Protocells: Modular mesoporous silica nanoparticle-supported lipid bilayers for drug delivery JO: Small http://www.kidney.de/pget.php?&tw=1&pmid=26780591 #FOAvip Mesoporous silica nanoparticle supported-lipid bilayers, termed ?protocells,? represent a potentially transformative class of therapeutic and theranostic delivery vehicles. The field of targeted drug delivery poses considerable challenges that cannot be addressed with a single ?magic bullet?. Consequently the protocell has been designed as a modular platform composed of interchangeable biocompatible components. The mesoporous silica core can have variable size and shape to direct biodistribution and controlled pore size and surface chemistry to accommodate diverse cargos. The encapsulating supported lipid bilayer can be modified with targeting and trafficking ligands as well as PEG to effect selective binding, endosomal escape of cargo, drug efflux prevention, and potent therapeutic delivery, while maintaining in vivo colloidal stability. This mini-review describes the individual components of the platform, including the mesoporous silica nanoparticle core and supported lipid bilayer, their assembly (by multiple techniques) into a protocell, and the combined, often synergistic, performance of the protocell based on in vitro and in vivo studies including assessment of biocompatibility and toxicity. We close by commenting on the many emerging variations of the protocell theme and the future directions for protocell research. Twit Text FOAVip Protocells: Modular mesoporous silica nanoparticle-supported lipid bilayers for drug delivery ????Small http://www.kidney.de/pget.php?&tw=1&pmid=26780591 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26780591 #FOAvip English Wikipedia <ref>{{Cite pmid|26780591}}</ref> Protocells: Modular mesoporous silica nanoparticle-supported lipid bilayers for drug delivery #MMPMID26780591 Butler KS; Durfee PN; Theron C; Ashley CE; Carnes EC; Brinker CJ Small 2016[Apr]; 12 (16): 2173-85 PMID26780591show ga Mesoporous silica nanoparticle supported-lipid bilayers, termed ?protocells,? represent a potentially transformative class of therapeutic and theranostic delivery vehicles. The field of targeted drug delivery poses considerable challenges that cannot be addressed with a single ?magic bullet?. Consequently the protocell has been designed as a modular platform composed of interchangeable biocompatible components. The mesoporous silica core can have variable size and shape to direct biodistribution and controlled pore size and surface chemistry to accommodate diverse cargos. The encapsulating supported lipid bilayer can be modified with targeting and trafficking ligands as well as PEG to effect selective binding, endosomal escape of cargo, drug efflux prevention, and potent therapeutic delivery, while maintaining in vivo colloidal stability. This mini-review describes the individual components of the platform, including the mesoporous silica nanoparticle core and supported lipid bilayer, their assembly (by multiple techniques) into a protocell, and the combined, often synergistic, performance of the protocell based on in vitro and in vivo studies including assessment of biocompatibility and toxicity. We close by commenting on the many emerging variations of the protocell theme and the future directions for protocell research. äProtocells: Modular mesoporous silica nanoparticle-supported lipid bil(epmc).pdf DeepDyve Pubget Overpricing