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10.1038/ncomms12231 http://scihub22266oqcxt.onion/10.1038/ncomms12231 C4963474!4963474!27456471     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27456471|t=2016. A genetic cell context-dependent role for ZEB1 in lung cancer |pdf=|usr=}}{{27456471}} gab.com Text A genetic cell context-dependent role for ZEB1 in lung cancer JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27456471 #FOAvip The Zinc-finger E-box-binding Homeobox-1 (ZEB1) is a transcription factor that promotes epithelial?mesenchymal transition (EMT) and acts as an oncogene in KRAS-mutated lung cancer models. Here we report that ZEB1 exerts the opposite effect in EGFR-mutated lung cancer cells, where it suppresses growth by increasing microRNA-200 targets to antagonize ERBB3, a driver of mutant EGFR-dependent cell growth. Among these targets, NOTCH1 represses ERBB3 promoter activity and the expression of ERBB3. Furthermore, we find that EGFR inhibitor treatment, which inhibits the growth of EGFR-mutated cells, induces ZEB1. Despite its growth-inhibiting effect, EGFR inhibitor-induced ZEB1 strongly promotes EMT-dependent resistance to EGFR inhibitors partially through NOTCH1, suggesting a multifunctional role for NOTCH1 in EGFR-mutated cells. These results support a previously unrecognized genetic cell context-dependent role for ZEB1 and suggest that NOTCH1 may be a useful target for treating resistance to EGFR inhibitors, especially EMT-driven resistance. Twit Text FOAVip A genetic cell context-dependent role for ZEB1 in lung cancer ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27456471 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27456471 #FOAvip English Wikipedia <ref>{{Cite pmid|27456471}}</ref> A genetic cell context-dependent role for ZEB1 in lung cancer #MMPMID27456471 Zhang T; Guo L; Creighton CJ; Lu Q; Gibbons DL; Yi ES; Deng B; Molina JR; Sun Z; Yang P; Yang Y Nat Commun 2016[]; 7 (ä): ä PMID27456471show ga The Zinc-finger E-box-binding Homeobox-1 (ZEB1) is a transcription factor that promotes epithelial?mesenchymal transition (EMT) and acts as an oncogene in KRAS-mutated lung cancer models. Here we report that ZEB1 exerts the opposite effect in EGFR-mutated lung cancer cells, where it suppresses growth by increasing microRNA-200 targets to antagonize ERBB3, a driver of mutant EGFR-dependent cell growth. Among these targets, NOTCH1 represses ERBB3 promoter activity and the expression of ERBB3. Furthermore, we find that EGFR inhibitor treatment, which inhibits the growth of EGFR-mutated cells, induces ZEB1. Despite its growth-inhibiting effect, EGFR inhibitor-induced ZEB1 strongly promotes EMT-dependent resistance to EGFR inhibitors partially through NOTCH1, suggesting a multifunctional role for NOTCH1 in EGFR-mutated cells. These results support a previously unrecognized genetic cell context-dependent role for ZEB1 and suggest that NOTCH1 may be a useful target for treating resistance to EGFR inhibitors, especially EMT-driven resistance. äA genetic cell context-dependent role for ZEB1 in lung cancer (epmc).pdf DeepDyve Pubget Overpricing