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10.1080/21645515.2015.1056954 http://scihub22266oqcxt.onion/10.1080/21645515.2015.1056954 C4962745!4962745 !26375414     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26375414 &cmd=llinks): Failed to open stream: HTTP request failed! 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Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons |pdf=|usr=}}{{26375414 }} gab.com Text Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons JO: Hum Vaccin Immunother http://www.kidney.de/pget.php?&tw=1&pmid=26375414 #FOAvip Dendritic structure is sensitive to changes in the environment during brain development. Accumulating evidence has demonstrated that early immune activation can significantly affect neuronal development. Our study concentrated on the morphological study of neural dendrites and spines in the hippocampal CA1 area using Diolistic labeling with Sholl analysis and fractal analysis. The results revealed that Bacille Calmette-Guérin (BCG) vaccination enhanced dendritic complexity, as reflected by the increased number of intersections, number of branch points and fractal dimension, and promoted neurite outgrowth. In addition, BCG increased the density and promoted the maturation of dendritic spines. The alterations in dendritic structure and spine morphology were observed at 2 and 4 w, but the differences were more apparent at 4 w than at 2 w. However, no significant difference was observed at 8 w. Furthermore, we observed that BCG increased the expression of hippocampal brain derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1). Hippocampal BDNF/IGF-1 was positively correlated with apical dendritic length, fractal dimension, and spine density. Taken together, we show in this study that neonatal BCG vaccination promotes dendritic development in developing hippocampal CA1 neurons, most likely by increasing the expression of BDNF and IGF-1 in the hippocampus. Twit Text FOAVip Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons ????Hum Vaccin Immunother http://www.kidney.de/pget.php?&tw=1&pmid=26375414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26375414 #FOAvip English Wikipedia <ref>{{Cite pmid|26375414 }}</ref> Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons #MMPMID26375414 Li Q ; Zhang Y ; Zou J ; Qi F ; Yang J ; Yuan Q ; Yao Z Hum Vaccin Immunother 2016[]; 12 (1 ): 140-9 PMID26375414 show ga Dendritic structure is sensitive to changes in the environment during brain development. Accumulating evidence has demonstrated that early immune activation can significantly affect neuronal development. Our study concentrated on the morphological study of neural dendrites and spines in the hippocampal CA1 area using Diolistic labeling with Sholl analysis and fractal analysis. The results revealed that Bacille Calmette-Guérin (BCG) vaccination enhanced dendritic complexity, as reflected by the increased number of intersections, number of branch points and fractal dimension, and promoted neurite outgrowth. In addition, BCG increased the density and promoted the maturation of dendritic spines. The alterations in dendritic structure and spine morphology were observed at 2 and 4 w, but the differences were more apparent at 4 w than at 2 w. However, no significant difference was observed at 8 w. Furthermore, we observed that BCG increased the expression of hippocampal brain derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1). Hippocampal BDNF/IGF-1 was positively correlated with apical dendritic length, fractal dimension, and spine density. Taken together, we show in this study that neonatal BCG vaccination promotes dendritic development in developing hippocampal CA1 neurons, most likely by increasing the expression of BDNF and IGF-1 in the hippocampus. |Animals [MESH] |Animals, Newborn [MESH] |BCG Vaccine/*administration & dosage [MESH] |Brain-Derived Neurotrophic Factor/biosynthesis [MESH] |CA1 Region, Hippocampal/*cytology/*growth & development [MESH] |Dendrites/*physiology [MESH] |Gene Expression [MESH] |Insulin-Like Growth Factor I/biosynthesis [MESH] |Neurons/*physiology [MESH]Neonatal vaccination with bacille Calmette-Guérin promotes the dendrit(epmc).pdf DeepDyve Pubget Overpricing