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10.1038/ncomms12171 http://scihub22266oqcxt.onion/10.1038/ncomms12171 C4961740!4961740 !27435370     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27435370 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 12171 Nephropedia Template TP {{tp|p=27435370 |t=2016. Human NK cell development requires CD56-mediated motility and formation of the developmental synapse |pdf=|usr=}}{{27435370 }} gab.com Text Human NK cell development requires CD56-mediated motility and formation of the developmental synapse JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27435370 #FOAvip While distinct stages of natural killer (NK) cell development have been defined, the molecular interactions that shape human NK cell maturation are poorly understood. Here we define intercellular interactions between developing NK cells and stromal cells which, through contact-dependent mechanisms, promote the generation of mature, functional human NK cells from CD34(+) precursors. We show that developing NK cells undergo unique, developmental stage-specific sustained and transient interactions with developmentally supportive stromal cells, and that the relative motility of NK cells increases as they move through development in vitro and ex vivo. These interactions include the formation of a synapse between developing NK cells and stromal cells, which we term the developmental synapse. Finally, we identify a role for CD56 in developmental synapse structure, NK cell motility and NK cell development. Thus, we define the developmental synapse leading to human NK cell functional maturation. Twit Text FOAVip Human NK cell development requires CD56-mediated motility and formation of the developmental synapse ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27435370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27435370 #FOAvip English Wikipedia <ref>{{Cite pmid|27435370 }}</ref> Human NK cell development requires CD56-mediated motility and formation of the developmental synapse #MMPMID27435370 Mace EM ; Gunesch JT ; Dixon A ; Orange JS Nat Commun 2016[Jul]; 7 (ä): 12171 PMID27435370 show ga While distinct stages of natural killer (NK) cell development have been defined, the molecular interactions that shape human NK cell maturation are poorly understood. Here we define intercellular interactions between developing NK cells and stromal cells which, through contact-dependent mechanisms, promote the generation of mature, functional human NK cells from CD34(+) precursors. We show that developing NK cells undergo unique, developmental stage-specific sustained and transient interactions with developmentally supportive stromal cells, and that the relative motility of NK cells increases as they move through development in vitro and ex vivo. These interactions include the formation of a synapse between developing NK cells and stromal cells, which we term the developmental synapse. Finally, we identify a role for CD56 in developmental synapse structure, NK cell motility and NK cell development. Thus, we define the developmental synapse leading to human NK cell functional maturation. |*Cell Movement [MESH] |Antibodies, Blocking/pharmacology [MESH] |CD56 Antigen/*metabolism [MESH] |Cell Differentiation [MESH] |Humans [MESH] |Immunological Synapses/drug effects/*metabolism [MESH] |Killer Cells, Natural/*cytology/drug effects/*metabolism [MESH] |Lymphocyte Subsets/cytology/metabolism [MESH] |Selectins/metabolism [MESH] |Signal Transduction [MESH] |Stromal Cells/cytology/metabolism [MESH]Human NK cell development requires CD56-mediated motility and formatio(epmc).pdf DeepDyve Pubget Overpricing