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10.1038/ncomms12111 http://scihub22266oqcxt.onion/10.1038/ncomms12111 C4961739!4961739!27435297     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27435297|t=2016. Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis |pdf=|usr=}}{{27435297}} gab.com Text Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27435297 #FOAvip Post-translational modifications are necessary for collagen precursor molecules (procollagens) to acquire final shape and function. However, the mechanism and contribution of collagen modifications that occur outside the endoplasmic reticulum and Golgi are not understood. We discovered that VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified post-Golgi collagen IV carriers and that VIPAR-dependent sorting is essential for modification of lysines in multiple collagen types. Identification of structural and functional collagen abnormalities in cells and tissues from patients and murine models of the autosomal recessive multisystem disorder Arthrogryposis, Renal dysfunction and Cholestasis syndrome caused by VIPAR and VPS33B deficiencies confirmed our findings. Thus, regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis and for the development and function of multiple organs and tissues. Twit Text FOAVip Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27435297 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27435297 #FOAvip English Wikipedia <ref>{{Cite pmid|27435297}}</ref> Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis #MMPMID27435297 Banushi B; Forneris F; Straatman-Iwanowska A; Strange A; Lyne AM; Rogerson C; Burden JJ; Heywood WE; Hanley J; Doykov I; Straatman KR; Smith H; Bem D; Kriston-Vizi J; Ariceta G; Risteli M; Wang C; Ardill RE; Zaniew M; Latka-Grot J; Waddington SN; Howe SJ; Ferraro F; Gjinovci A; Lawrence S; Marsh M; Girolami M; Bozec L; Mills K; Gissen P Nat Commun 2016[]; 7 (ä): ä PMID27435297show ga Post-translational modifications are necessary for collagen precursor molecules (procollagens) to acquire final shape and function. However, the mechanism and contribution of collagen modifications that occur outside the endoplasmic reticulum and Golgi are not understood. We discovered that VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified post-Golgi collagen IV carriers and that VIPAR-dependent sorting is essential for modification of lysines in multiple collagen types. Identification of structural and functional collagen abnormalities in cells and tissues from patients and murine models of the autosomal recessive multisystem disorder Arthrogryposis, Renal dysfunction and Cholestasis syndrome caused by VIPAR and VPS33B deficiencies confirmed our findings. Thus, regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis and for the development and function of multiple organs and tissues. äRegulation of post-Golgi LH3 trafficking is essential for collagen hom(epmc).pdf DeepDyve Pubget Overpricing