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10.1128/MCB.00019-16 http://scihub22266oqcxt.onion/10.1128/MCB.00019-16 C4959312!4959312 !27044866     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27044866 &cmd=llinks): Failed to open stream: HTTP request failed! 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Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition |pdf=|usr=}}{{27044866 }} gab.com Text Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27044866 #FOAvip The epithelial-to-mesenchymal transition (EMT) is an essential biological process during embryonic development that is also implicated in cancer metastasis. While the transcriptional regulation of EMT has been well studied, the role of alternative splicing (AS) regulation in EMT remains relatively uncharacterized. We previously showed that the epithelial cell-type-specific proteins epithelial splicing regulatory proteins 1 (ESRP1) and ESRP2 are important for the regulation of many AS events that are altered during EMT. However, the contributions of the ESRPs and other splicing regulators to the AS regulatory network in EMT require further investigation. Here, we used a robust in vitro EMT model to comprehensively characterize splicing switches during EMT in a temporal manner. These investigations revealed that the ESRPs are the major regulators of some but not all AS events during EMT. We determined that the splicing factor RBM47 is downregulated during EMT and also regulates numerous transcripts that switch splicing during EMT. We also determined that Quaking (QKI) broadly promotes mesenchymal splicing patterns. Our study highlights the broad role of posttranscriptional regulation during the EMT and the important role of combinatorial regulation by different splicing factors to fine tune gene expression programs during these physiological and developmental transitions. Twit Text FOAVip Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27044866 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27044866 #FOAvip English Wikipedia <ref>{{Cite pmid|27044866 }}</ref> Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition #MMPMID27044866 Yang Y ; Park JW ; Bebee TW ; Warzecha CC ; Guo Y ; Shang X ; Xing Y ; Carstens RP Mol Cell Biol 2016[Jun]; 36 (11 ): 1704-19 PMID27044866 show ga The epithelial-to-mesenchymal transition (EMT) is an essential biological process during embryonic development that is also implicated in cancer metastasis. While the transcriptional regulation of EMT has been well studied, the role of alternative splicing (AS) regulation in EMT remains relatively uncharacterized. We previously showed that the epithelial cell-type-specific proteins epithelial splicing regulatory proteins 1 (ESRP1) and ESRP2 are important for the regulation of many AS events that are altered during EMT. However, the contributions of the ESRPs and other splicing regulators to the AS regulatory network in EMT require further investigation. Here, we used a robust in vitro EMT model to comprehensively characterize splicing switches during EMT in a temporal manner. These investigations revealed that the ESRPs are the major regulators of some but not all AS events during EMT. We determined that the splicing factor RBM47 is downregulated during EMT and also regulates numerous transcripts that switch splicing during EMT. We also determined that Quaking (QKI) broadly promotes mesenchymal splicing patterns. Our study highlights the broad role of posttranscriptional regulation during the EMT and the important role of combinatorial regulation by different splicing factors to fine tune gene expression programs during these physiological and developmental transitions. |*Alternative Splicing [MESH] |*Epithelial-Mesenchymal Transition [MESH] |*Gene Regulatory Networks [MESH] |Cell Line, Tumor [MESH] |Down-Regulation [MESH] |Humans [MESH] |Models, Biological [MESH] |Neoplasms/*genetics [MESH] |RNA-Binding Proteins/genetics [MESH]Determination of a Comprehensive Alternative Splicing Regulatory Netwo(epmc).pdf DeepDyve Pubget Overpricing