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2016 ; 95
(2
): 412-29
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Virus and host genomic, molecular, and cellular interactions during Marek s
disease pathogenesis and oncogenesis
#MMPMID26755654
McPherson MC
; Delany ME
Poult Sci
2016[Feb]; 95
(2
): 412-29
PMID26755654
show ga
Marek's Disease Virus (MDV) is a chicken alphaherpesvirus that causes paralysis,
chronic wasting, blindness, and fatal lymphoma development in infected,
susceptible host birds. This disease and its protective vaccines are highly
relevant research targets, given their enormous impact within the poultry
industry. Further, Marek's disease (MD) serves as a valuable model for the
investigation of oncogenic viruses and herpesvirus patterns of viral latency and
persistence--as pertinent to human health as to poultry health. The objectives of
this article are to review MDV interactions with its host from a variety of
genomic, molecular, and cellular perspectives. In particular, we focus on
cytogenetic studies, which precisely assess the physical status of the MDV genome
in the context of the chicken host genome. Combined, the cytogenetic and genomic
research indicates that MDV-host genome interactions, specifically integration of
the virus into the host telomeres, is a key feature of the virus life cycle,
contributing to the viral achievement of latency, transformation, and
reactivation of lytic replication. We present a model that outlines the variety
of virus-host interactions, at the multiple levels, and with regard to the
disease states.