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10.1016/j.jpsychires.2015.05.007 http://scihub22266oqcxt.onion/10.1016/j.jpsychires.2015.05.007 C4955923!4955923 !26028548     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26028548 &cmd=llinks): Failed to open stream: HTTP request failed! 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Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies |pdf=|usr=}}{{26028548 }} gab.com Text Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies JO: J Psychiatr Res http://www.kidney.de/pget.php?&tw=1&pmid=26028548 #FOAvip Treatment-resistant depression affects up to 20% of individuals suffering from major depressive disorder (MDD). The medications currently available to treat depression, including serotonin re-uptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs), fail to produce adequate remission of depressive symptoms for a large number of patients. The monoamine hypothesis upon which these medications are predicated should be expanded and revised as research elucidates alternative mechanisms of depression and effective methods to treat the underlying pathologic consequences. Research into the role of tryptophan degradation and the kynurenine pathway in the setting of inflammation has brought new insight into potential etiologies of MDD. Further investigation into the connection between inflammatory mediators, tryptophan degradation, and MDD can provide many targets for novel antidepressant therapies. Thus, this review will highlight the role of the kynurenine pathway in the pathophysiology of depression, as well as a novel therapeutic target to classic and new modulators to treat depression based on findings from preclinical and clinical studies. Twit Text FOAVip Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies ????J Psychiatr Res http://www.kidney.de/pget.php?&tw=1&pmid=26028548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26028548 #FOAvip English Wikipedia <ref>{{Cite pmid|26028548 }}</ref> Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies #MMPMID26028548 Réus GZ ; Jansen K ; Titus S ; Carvalho AF ; Gabbay V ; Quevedo J J Psychiatr Res 2015[Sep]; 68 (ä): 316-28 PMID26028548 show ga Treatment-resistant depression affects up to 20% of individuals suffering from major depressive disorder (MDD). The medications currently available to treat depression, including serotonin re-uptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs), fail to produce adequate remission of depressive symptoms for a large number of patients. The monoamine hypothesis upon which these medications are predicated should be expanded and revised as research elucidates alternative mechanisms of depression and effective methods to treat the underlying pathologic consequences. Research into the role of tryptophan degradation and the kynurenine pathway in the setting of inflammation has brought new insight into potential etiologies of MDD. Further investigation into the connection between inflammatory mediators, tryptophan degradation, and MDD can provide many targets for novel antidepressant therapies. Thus, this review will highlight the role of the kynurenine pathway in the pathophysiology of depression, as well as a novel therapeutic target to classic and new modulators to treat depression based on findings from preclinical and clinical studies. |Animals [MESH] |Depressive Disorder, Major/drug therapy/*metabolism [MESH] |Humans [MESH] |Kynurenine/*metabolism [MESH]Kynurenine pathway dysfunction in the pathophysiology and treatment of(epmc).pdf DeepDyve Pubget Overpricing