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10.1007/s00018-016-2201-6

http://scihub22266oqcxt.onion/10.1007/s00018-016-2201-6
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C4955867!4955867!27066896
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suck abstract from ncbi

pmid27066896      Cell+Mol+Life+Sci 2016 ; 73 (11-12): 2285-308
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  • THE ROLE OF GLYCINE IN REGULATED CELL DEATH #MMPMID27066896
  • WEINBERG JM; BIENHOLZ A; VENKATACHALAM M
  • Cell Mol Life Sci 2016[Jun]; 73 (11-12): 2285-308 PMID27066896show ga
  • The cytoprotective effects of glycine against cell death have been recognized for over 28 years. They are expressed in multiple cell types and injury settings that lead to necrosis, but are still not widely appreciated or considered in the conceptualization of cell death pathways. In this paper we review the available data on the expression of this phenomenon, its relationship to major pathophysiologic pathways that lead to cell death and immunomodulatory effects, the hypothesis that it involves suppression by glycine of the development of a hydrophilic death channel of molecular dimensions in the plasma membrane, and evidence for its impact on disease processes in vivo.
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