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10.1016/j.mce.2016.05.018 http://scihub22266oqcxt.onion/10.1016/j.mce.2016.05.018 C4955520!4955520!27222295     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Endocrinol 2016 ; 433 (ä): 138-46 Nephropedia Template TP {{tp|p=27222295|t=2016. VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production |pdf=|usr=}}{{27222295}} gab.com Text VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production JO: Mol Cell Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=27222295 #FOAvip Aldosterone plays an important role in regulating ion and fluid homeostasis and thus blood pressure, and hyperaldosteronism results in hypertension. Hypertension is also observed with obesity, which is associated with additional health risks, including cardiovascular disease. Obese individuals have high serum levels of very low-density lipoprotein (VLDL), which has been shown to stimulate aldosterone production; however, the mechanisms underlying VLDL-induced aldosterone production are still unclear. Here we demonstrate in human adrenocortical carcinoma (HAC15) cells that submaximal concentrations of angiotensin II and VLDL stimulate aldosterone production in an additive fashion, suggesting the possibility of common mechanisms of action. We show using inhibitors that VLDL-induced aldosterone production is mediated by the PLC/IP3/PKC signaling pathway. Our results suggest that PKC is upstream of the extracellular signal-regulated kinase (ERK) activation previously observed with VLDL. An understanding of the mechanisms mediating VLDL-induced aldosterone production may provide insights into therapies to treat obesity-associated hypertension. Twit Text FOAVip VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production ????Mol Cell Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=27222295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27222295 #FOAvip English Wikipedia <ref>{{Cite pmid|27222295}}</ref> VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production #MMPMID27222295 Tsai YY; Rainey WE; Johnson MH; Bollag WB Mol Cell Endocrinol 2016[Sep]; 433 (ä): 138-46 PMID27222295show ga Aldosterone plays an important role in regulating ion and fluid homeostasis and thus blood pressure, and hyperaldosteronism results in hypertension. Hypertension is also observed with obesity, which is associated with additional health risks, including cardiovascular disease. Obese individuals have high serum levels of very low-density lipoprotein (VLDL), which has been shown to stimulate aldosterone production; however, the mechanisms underlying VLDL-induced aldosterone production are still unclear. Here we demonstrate in human adrenocortical carcinoma (HAC15) cells that submaximal concentrations of angiotensin II and VLDL stimulate aldosterone production in an additive fashion, suggesting the possibility of common mechanisms of action. We show using inhibitors that VLDL-induced aldosterone production is mediated by the PLC/IP3/PKC signaling pathway. Our results suggest that PKC is upstream of the extracellular signal-regulated kinase (ERK) activation previously observed with VLDL. An understanding of the mechanisms mediating VLDL-induced aldosterone production may provide insights into therapies to treat obesity-associated hypertension. äVLDL-activated cell signaling pathways that stimulate adrenal cell ald(epmc).pdf DeepDyve Pubget Overpricing