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10.1002/chem.201504936

http://scihub22266oqcxt.onion/10.1002/chem.201504936
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C4955406!4955406!26945679
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suck abstract from ncbi

pmid26945679      Chemistry 2016 ; 22 (16): 5458-66
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  • ?-AApeptides as a new class of peptidomimetics #MMPMID26945679
  • Teng P; Shi Y; Sang P; Cai J
  • Chemistry 2016[Apr]; 22 (16): 5458-66 PMID26945679show ga
  • Sequence-specific peptidomimetics are molecules that mimic structure and function of peptides and proteins. With new backbones and molecular frameworks, peptidomimetics are of considerable interest to address challenges encountered in chemical biology and biomedical sciences. Based on the ?-PNA backbone, a new class of peptidomimetics - "?-AApeptides" were recently developed. Both linear and cyclic ?-AApeptides can be synthesized with high efficiency. Compared with ?-peptides, ?-AApeptides are resistant to enzymatic degradation, and amendable to diversification with a variety of chemical groups. Moreover, they could mimic primary and secondary structure, as well as function of peptides, and show promise in biological applications, such as development of new agents combating bacteria, cancer, and Alzheimer?s disease (AD). A few research outcomes of ?-AApeptides are highlighted in this concept article, and a future perspective is also proposed.
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