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10.1189/jlb.3MA0915-418R http://scihub22266oqcxt.onion/10.1189/jlb.3MA0915-418R C4952013!4952013 !26868525     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26868525 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Leukoc+Biol 2016 ; 99 (6 ): 1035-43 Nephropedia Template TP {{tp|p=26868525 |t=2016. Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1? production in a murine model of acute gout |pdf=|usr=}}{{26868525 }} gab.com Text Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1 production in a murine model of acute gout JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=26868525 #FOAvip This study evaluated the role of macrophage migration inhibitory factor in inflammation caused by monosodium urate crystals. The concentration of macrophage migration inhibitory factor was increased in synovial fluid of patients with acute gout, and there was a positive correlation between intra-articular macrophage migration inhibitory factor and IL-1? concentrations. In mice, the injection of monosodium urate crystals into the knee joint increased the levels of macrophage migration inhibitory factor in macrophages and in inflamed tissue. The injection of recombinant macrophage migration inhibitory factor into the joint of mice reproduced the inflammatory response observed in acute gout, including histologic changes, the recruitment of neutrophils, and increased levels of IL-1? and CXCL1. Importantly, the accumulation of neutrophils and the amount IL-1? in the joints were reduced in macrophage migration inhibitory factor-deficient mice when injected with monosodium urate crystals. We observed a similar effect when we blocked macrophage migration inhibitory factor with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid or anti-macrophage migration inhibitory factor. In addition, the blockade of IL-1R and CXCR2 reduced recombinant macrophage migration inhibitory factor-induced neutrophil recruitment. Mechanistically, recombinant macrophage migration inhibitory factor is important for the synthesis of il1? mRNA in vivo and in isolated macrophages. Altogether, macrophage migration inhibitory factor promotes neutrophil accumulation and is important for IL-1? production, which are 2 crucial events contributing to the pathogenesis of acute gout. Twit Text FOAVip Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1 production in a murine model of acute gout ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=26868525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26868525 #FOAvip English Wikipedia <ref>{{Cite pmid|26868525 }}</ref> Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1? production in a murine model of acute gout #MMPMID26868525 Galvão I ; Dias AC ; Tavares LD ; Rodrigues IP ; Queiroz-Junior CM ; Costa VV ; Reis AC ; Ribeiro Oliveira RD ; Louzada-Junior P ; Souza DG ; Leng L ; Bucala R ; Sousa LP ; Bozza MT ; Teixeira MM ; Amaral FA J Leukoc Biol 2016[Jun]; 99 (6 ): 1035-43 PMID26868525 show ga This study evaluated the role of macrophage migration inhibitory factor in inflammation caused by monosodium urate crystals. The concentration of macrophage migration inhibitory factor was increased in synovial fluid of patients with acute gout, and there was a positive correlation between intra-articular macrophage migration inhibitory factor and IL-1? concentrations. In mice, the injection of monosodium urate crystals into the knee joint increased the levels of macrophage migration inhibitory factor in macrophages and in inflamed tissue. The injection of recombinant macrophage migration inhibitory factor into the joint of mice reproduced the inflammatory response observed in acute gout, including histologic changes, the recruitment of neutrophils, and increased levels of IL-1? and CXCL1. Importantly, the accumulation of neutrophils and the amount IL-1? in the joints were reduced in macrophage migration inhibitory factor-deficient mice when injected with monosodium urate crystals. We observed a similar effect when we blocked macrophage migration inhibitory factor with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid or anti-macrophage migration inhibitory factor. In addition, the blockade of IL-1R and CXCR2 reduced recombinant macrophage migration inhibitory factor-induced neutrophil recruitment. Mechanistically, recombinant macrophage migration inhibitory factor is important for the synthesis of il1? mRNA in vivo and in isolated macrophages. Altogether, macrophage migration inhibitory factor promotes neutrophil accumulation and is important for IL-1? production, which are 2 crucial events contributing to the pathogenesis of acute gout. |Acute Disease [MESH] |Animals [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Gout/*metabolism/*pathology [MESH] |Humans [MESH] |Inflammation/pathology [MESH] |Injections [MESH] |Interleukin-1beta/*biosynthesis [MESH] |Joints/drug effects/pathology [MESH] |Macrophage Migration-Inhibitory Factors/deficiency/*metabolism [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Middle Aged [MESH] |Neutrophils/drug effects/*metabolism [MESH] |RNA, Messenger/biosynthesis/genetics/metabolism [MESH] |Receptors, Interleukin-1/genetics/metabolism [MESH] |Receptors, Interleukin-8A/metabolism [MESH] |Receptors, Interleukin-8B/metabolism [MESH] |Recombinant Proteins/pharmacology [MESH] |Synovial Fluid/drug effects/metabolism [MESH]Macrophage migration inhibitory factor drives neutrophil accumulation (epmc).pdf DeepDyve Pubget Overpricing