Strategies to Target Non-T cell HIV Reservoirs #MMPMID27023285
Sacha JB; Ndhlovu LC
Curr Opin HIV AIDS 2016[Jul]; 11 (4): 376-82 PMID27023285show ga
Purpose: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4+ T cells, particularly in anatomical areas of low drug penetrability. Recent findings: HIV eradication strategies being positioned for targeting HIV for extinction in the CD4 T cell compartment may also show promise in non-CD4 T cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4 T cells populations are being developed. Summary: Although reservoir validity in these non-CD4 T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure.