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10.1074/jbc.M116.730408 http://scihub22266oqcxt.onion/10.1074/jbc.M116.730408 C4946929!4946929!27226618     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2016 ; 291 (29): 15131-42 Nephropedia Template TP {{tp|p=27226618|t=2016. Central Leptin and Tumor Necrosis Factor-? (TNF?) in Diurnal Control of Blood Pressure and Hypertension* |pdf=|usr=}}{{27226618}} gab.com Text Central Leptin and Tumor Necrosis Factor- (TNF ) in Diurnal Control of Blood Pressure and Hypertension* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27226618 #FOAvip Leptin and TNF? can individually work in the brain to affect blood pressure; however, it remains unknown whether these two cytokines might have an interactive role in this process and, if so, how. In this work, we found that leptin stimulation led to TNF? production under both in vitro and in vivo conditions, and diurnal fluctuation of leptin concentrations in the cerebrospinal fluid predicted the circadian changes of TNF? gene expression in the hypothalamus. Signaling analysis showed that leptin stimulation led to a rapid and strong STAT3 activation followed by a second-phase moderate STAT3 activation, which was selectively abolished by anti-inflammatory chemical PS1145 or TNF? antagonist WP9QY. Physiological study in normal mice revealed that diurnal rise of blood pressure was abrogated following central administration of PS1145 or a leptin receptor antagonist. Central TNF? pretreatment was found to potentiate the effect of leptin in elevating blood pressure in normal mice. In pathophysiology, dietary obesity mimicked TNF? pretreatment in promoting leptin-induced blood pressure rise, and this effect was blocked by central treatment with either PS1145 or WP9QY. Hence, central leptin employs TNF? to mediate the diurnal blood pressure elevation in physiology while enhancement of this mechanism can contribute to hypertension development. Twit Text FOAVip Central Leptin and Tumor Necrosis Factor- (TNF ) in Diurnal Control of Blood Pressure and Hypertension* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27226618 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27226618 #FOAvip English Wikipedia <ref>{{Cite pmid|27226618}}</ref> Central Leptin and Tumor Necrosis Factor-? (TNF?) in Diurnal Control of Blood Pressure and Hypertension* #MMPMID27226618 Han C; Wu W; Ale A; Kim MS; Cai D J Biol Chem 2016[Jul]; 291 (29): 15131-42 PMID27226618show ga Leptin and TNF? can individually work in the brain to affect blood pressure; however, it remains unknown whether these two cytokines might have an interactive role in this process and, if so, how. In this work, we found that leptin stimulation led to TNF? production under both in vitro and in vivo conditions, and diurnal fluctuation of leptin concentrations in the cerebrospinal fluid predicted the circadian changes of TNF? gene expression in the hypothalamus. Signaling analysis showed that leptin stimulation led to a rapid and strong STAT3 activation followed by a second-phase moderate STAT3 activation, which was selectively abolished by anti-inflammatory chemical PS1145 or TNF? antagonist WP9QY. Physiological study in normal mice revealed that diurnal rise of blood pressure was abrogated following central administration of PS1145 or a leptin receptor antagonist. Central TNF? pretreatment was found to potentiate the effect of leptin in elevating blood pressure in normal mice. In pathophysiology, dietary obesity mimicked TNF? pretreatment in promoting leptin-induced blood pressure rise, and this effect was blocked by central treatment with either PS1145 or WP9QY. Hence, central leptin employs TNF? to mediate the diurnal blood pressure elevation in physiology while enhancement of this mechanism can contribute to hypertension development. äCentral Leptin and Tumor Necrosis Factor-? (TNF?) in Diurnal Control o(epmc).pdf DeepDyve Pubget Overpricing