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10.1038/cdd.2015.160 http://scihub22266oqcxt.onion/10.1038/cdd.2015.160 C4946882!4946882 !26742431     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26742431 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Differ 2016 ; 23 (7 ): 1140-51 Nephropedia Template TP {{tp|p=26742431 |t=2016. NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy |pdf=|usr=}}{{26742431 }} gab.com Text NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26742431 #FOAvip Mitophagy is critical for cell homeostasis. Externalization of the inner mitochondrial membrane phospholipid, cardiolipin (CL), to the surface of the outer mitochondrial membrane (OMM) was identified as a mitophageal signal recognized by the microtubule-associated protein 1 light chain 3. However, the CL-translocating machinery remains unknown. Here we demonstrate that a hexameric intermembrane space protein, NDPK-D (or NM23-H4), binds CL and facilitates its redistribution to the OMM. We found that mitophagy induced by a protonophoric uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCCP), caused externalization of CL to the surface of mitochondria in murine lung epithelial MLE-12 cells and human cervical adenocarcinoma HeLa cells. RNAi knockdown of endogenous NDPK-D decreased CCCP-induced CL externalization and mitochondrial degradation. A R90D NDPK-D mutant that does not bind CL was inactive in promoting mitophagy. Similarly, rotenone and 6-hydroxydopamine triggered mitophagy in SH-SY5Y cells was also suppressed by knocking down of NDPK-D. In situ proximity ligation assay (PLA) showed that mitophagy-inducing CL-transfer activity of NDPK-D is closely associated with the dynamin-like GTPase OPA1, implicating fission-fusion dynamics in mitophagy regulation. Twit Text FOAVip NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26742431 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26742431 #FOAvip English Wikipedia <ref>{{Cite pmid|26742431 }}</ref> NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy #MMPMID26742431 Kagan VE ; Jiang J ; Huang Z ; Tyurina YY ; Desbourdes C ; Cottet-Rousselle C ; Dar HH ; Verma M ; Tyurin VA ; Kapralov AA ; Cheikhi A ; Mao G ; Stolz D ; St Croix CM ; Watkins S ; Shen Z ; Li Y ; Greenberg ML ; Tokarska-Schlattner M ; Boissan M ; Lacombe ML ; Epand RM ; Chu CT ; Mallampalli RK ; Bay?r H ; Schlattner U Cell Death Differ 2016[Jul]; 23 (7 ): 1140-51 PMID26742431 show ga Mitophagy is critical for cell homeostasis. Externalization of the inner mitochondrial membrane phospholipid, cardiolipin (CL), to the surface of the outer mitochondrial membrane (OMM) was identified as a mitophageal signal recognized by the microtubule-associated protein 1 light chain 3. However, the CL-translocating machinery remains unknown. Here we demonstrate that a hexameric intermembrane space protein, NDPK-D (or NM23-H4), binds CL and facilitates its redistribution to the OMM. We found that mitophagy induced by a protonophoric uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCCP), caused externalization of CL to the surface of mitochondria in murine lung epithelial MLE-12 cells and human cervical adenocarcinoma HeLa cells. RNAi knockdown of endogenous NDPK-D decreased CCCP-induced CL externalization and mitochondrial degradation. A R90D NDPK-D mutant that does not bind CL was inactive in promoting mitophagy. Similarly, rotenone and 6-hydroxydopamine triggered mitophagy in SH-SY5Y cells was also suppressed by knocking down of NDPK-D. In situ proximity ligation assay (PLA) showed that mitophagy-inducing CL-transfer activity of NDPK-D is closely associated with the dynamin-like GTPase OPA1, implicating fission-fusion dynamics in mitophagy regulation. |*Mitophagy/drug effects [MESH] |Animals [MESH] |Autophagy/drug effects [MESH] |Carbonyl Cyanide m-Chlorophenyl Hydrazone/toxicity [MESH] |Cardiolipins/analysis/*metabolism [MESH] |Cell Line [MESH] |GTP Phosphohydrolases/metabolism [MESH] |HeLa Cells [MESH] |Humans [MESH] |Lysosomes/metabolism/pathology [MESH] |Mice [MESH] |Microtubule-Associated Proteins/metabolism [MESH] |Mitochondria/*metabolism/pathology [MESH] |Mitochondrial Membranes/*metabolism [MESH] |Mutagenesis, Site-Directed [MESH] |Nucleoside Diphosphate Kinase D/antagonists & inhibitors/genetics/*metabolism [MESH] |Oxidopamine/pharmacology [MESH] |Protein Binding [MESH] |RNA Interference [MESH]NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimi(epmc).pdf DeepDyve Pubget Overpricing