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10.1097/MCO.0000000000000267 http://scihub22266oqcxt.onion/10.1097/MCO.0000000000000267 C4946244!4946244!26870889     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Clin+Nutr+Metab+Care 2016 ; 19 (3): 177-81 Nephropedia Template TP {{tp|p=26870889|t=2016. Neuromuscular Junction Degeneration In Muscle Wasting |pdf=|usr=}}{{26870889}} gab.com Text Neuromuscular Junction Degeneration In Muscle Wasting JO: Curr Opin Clin Nutr Metab Care http://www.kidney.de/pget.php?&tw=1&pmid=26870889 #FOAvip Purpose of review: Denervation is a hallmark of age-related and other types of muscle wasting. This review focuses on recent insights and current viewpoints regarding the mechanisms and clinical relevance of maintaining the neuromuscular junction to counteract muscle wasting resulting from aging or neural disease/damage. Recent findings: Activity-dependent regulation of autophagy, the agrin-MuSK-Lrp4 signaling axis, and sympathetic modulation are principal mechanisms involved in stabilizing the neuromuscular junction. These findings are derived from several animal models and were largely confirmed by human gene expression analysis as well as insights from rare neuromuscular diseases such as amyotrophic lateral sclerosis and congenital myasthenic syndromes. Based on these insights, agrin-derived fragments are currently being evaluated as biomarkers for age-related muscle wasting. Tuning of autophagy, of the agrin pathway, and of sympathetic input are being studied as clinical treatment of muscle wasting disorders. Summary: Basic research has revealed that maintenance of neuromuscular junctions and a few signaling pathways are important in the context of age-dependent and other forms of muscle wasting. These findings have recently started to enter clinical practice, but further research needs to substantiate and refine our knowledge. Twit Text FOAVip Neuromuscular Junction Degeneration In Muscle Wasting ????Curr Opin Clin Nutr Metab Care http://www.kidney.de/pget.php?&tw=1&pmid=26870889 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26870889 #FOAvip English Wikipedia <ref>{{Cite pmid|26870889}}</ref> Neuromuscular Junction Degeneration In Muscle Wasting #MMPMID26870889 Rudolf R; Deschenes MR; Sandri M Curr Opin Clin Nutr Metab Care 2016[May]; 19 (3): 177-81 PMID26870889show ga Purpose of review: Denervation is a hallmark of age-related and other types of muscle wasting. This review focuses on recent insights and current viewpoints regarding the mechanisms and clinical relevance of maintaining the neuromuscular junction to counteract muscle wasting resulting from aging or neural disease/damage. Recent findings: Activity-dependent regulation of autophagy, the agrin-MuSK-Lrp4 signaling axis, and sympathetic modulation are principal mechanisms involved in stabilizing the neuromuscular junction. These findings are derived from several animal models and were largely confirmed by human gene expression analysis as well as insights from rare neuromuscular diseases such as amyotrophic lateral sclerosis and congenital myasthenic syndromes. Based on these insights, agrin-derived fragments are currently being evaluated as biomarkers for age-related muscle wasting. Tuning of autophagy, of the agrin pathway, and of sympathetic input are being studied as clinical treatment of muscle wasting disorders. Summary: Basic research has revealed that maintenance of neuromuscular junctions and a few signaling pathways are important in the context of age-dependent and other forms of muscle wasting. These findings have recently started to enter clinical practice, but further research needs to substantiate and refine our knowledge. äNeuromuscular Junction Degeneration In Muscle Wasting (epmc).pdf DeepDyve Pubget Overpricing