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10.1038/ncomms12134 http://scihub22266oqcxt.onion/10.1038/ncomms12134 C4942579!4942579 !27396388     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27396388 &cmd=llinks): Failed to open stream: HTTP request failed! 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Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells |pdf=|usr=}}{{27396388 }} gab.com Text Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27396388 #FOAvip The influence of signals perceived by immature B cells during their development in bone marrow on their subsequent functions as mature cells are poorly defined. Here, we show that bone marrow cells transiently stimulated in vivo or in vitro through the Toll-like receptor 9 generate proB cells (CpG-proBs) that interrupt experimental autoimmune encephalomyelitis (EAE) when transferred at the onset of clinical symptoms. Protection requires differentiation of CpG-proBs into mature B cells that home to reactive lymph nodes, where they trap T cells by releasing the CCR7 ligand, CCL19, and to inflamed central nervous system, where they locally limit immunopathogenesis through interleukin-10 production, thereby cooperatively inhibiting ongoing EAE. These data demonstrate that a transient inflammation at the environment, where proB cells develop, is sufficient to confer regulatory functions onto their mature B-cell progeny. In addition, these properties of CpG-proBs open interesting perspectives for cell therapy of autoimmune diseases. Twit Text FOAVip Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27396388 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27396388 #FOAvip English Wikipedia <ref>{{Cite pmid|27396388 }}</ref> Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells #MMPMID27396388 Korniotis S ; Gras C ; Letscher H ; Montandon R ; Mégret J ; Siegert S ; Ezine S ; Fallon PG ; Luther SA ; Fillatreau S ; Zavala F Nat Commun 2016[Jul]; 7 (ä): 12134 PMID27396388 show ga The influence of signals perceived by immature B cells during their development in bone marrow on their subsequent functions as mature cells are poorly defined. Here, we show that bone marrow cells transiently stimulated in vivo or in vitro through the Toll-like receptor 9 generate proB cells (CpG-proBs) that interrupt experimental autoimmune encephalomyelitis (EAE) when transferred at the onset of clinical symptoms. Protection requires differentiation of CpG-proBs into mature B cells that home to reactive lymph nodes, where they trap T cells by releasing the CCR7 ligand, CCL19, and to inflamed central nervous system, where they locally limit immunopathogenesis through interleukin-10 production, thereby cooperatively inhibiting ongoing EAE. These data demonstrate that a transient inflammation at the environment, where proB cells develop, is sufficient to confer regulatory functions onto their mature B-cell progeny. In addition, these properties of CpG-proBs open interesting perspectives for cell therapy of autoimmune diseases. |*Bone Marrow Transplantation [MESH] |Animals [MESH] |B-Lymphocytes, Regulatory/cytology/*physiology [MESH] |Cell Differentiation [MESH] |Cell Movement [MESH] |Chemokine CCL19/physiology [MESH] |Encephalomyelitis, Autoimmune, Experimental/*therapy [MESH] |Female [MESH] |Interferon-gamma/metabolism [MESH] |Interleukin-10/metabolism [MESH] |Lymph Nodes/physiology [MESH] |Mice, Inbred C57BL [MESH] |Oligodeoxyribonucleotides [MESH]Treatment of ongoing autoimmune encephalomyelitis with activated B-cel(epmc).pdf DeepDyve Pubget Overpricing