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10.1038/ncomms12177 http://scihub22266oqcxt.onion/10.1038/ncomms12177 C4942576!4942576 !27397585     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27397585 &cmd=llinks): Failed to open stream: HTTP request failed! 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Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution |pdf=|usr=}}{{27397585 }} gab.com Text Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27397585 #FOAvip Inflammation resolution is an active process, the failure of which causes uncontrolled inflammation which underlies many chronic diseases. Therefore, endogenous pathways that regulate inflammation resolution are fundamental and of wide interest. Here, we demonstrate that phagocyte respiratory burst-induced hypoxia activates macrophage erythropoietin signalling to promote acute inflammation resolution. This signalling is activated following acute but not chronic inflammation. Pharmacological or genetical inhibition of the respiratory burst suppresses hypoxia and macrophage erythropoietin signalling. Macrophage-specific erythropoietin receptor-deficient mice and chronic granulomatous disease (CGD) mice, which lack the capacity for respiratory burst, display impaired inflammation resolution, and exogenous erythropoietin enhances this resolution in WT and CGD mice. Mechanistically, erythropoietin increases macrophage engulfment of apoptotic neutrophils via PPAR?, promotes macrophage removal of debris and enhances macrophage migration to draining lymph nodes. Together, our results provide evidences of an endogenous pathway that regulates inflammation resolution, with important implications for treating inflammatory conditions. Twit Text FOAVip Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27397585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27397585 #FOAvip English Wikipedia <ref>{{Cite pmid|27397585 }}</ref> Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution #MMPMID27397585 Luo B ; Wang J ; Liu Z ; Shen Z ; Shi R ; Liu YQ ; Liu Y ; Jiang M ; Wu Y ; Zhang Z Nat Commun 2016[Jul]; 7 (ä): 12177 PMID27397585 show ga Inflammation resolution is an active process, the failure of which causes uncontrolled inflammation which underlies many chronic diseases. Therefore, endogenous pathways that regulate inflammation resolution are fundamental and of wide interest. Here, we demonstrate that phagocyte respiratory burst-induced hypoxia activates macrophage erythropoietin signalling to promote acute inflammation resolution. This signalling is activated following acute but not chronic inflammation. Pharmacological or genetical inhibition of the respiratory burst suppresses hypoxia and macrophage erythropoietin signalling. Macrophage-specific erythropoietin receptor-deficient mice and chronic granulomatous disease (CGD) mice, which lack the capacity for respiratory burst, display impaired inflammation resolution, and exogenous erythropoietin enhances this resolution in WT and CGD mice. Mechanistically, erythropoietin increases macrophage engulfment of apoptotic neutrophils via PPAR?, promotes macrophage removal of debris and enhances macrophage migration to draining lymph nodes. Together, our results provide evidences of an endogenous pathway that regulates inflammation resolution, with important implications for treating inflammatory conditions. |*Phagocytosis [MESH] |*Respiratory Burst [MESH] |Animals [MESH] |Cell Movement [MESH] |Erythropoietin/*metabolism [MESH] |Hypoxia/metabolism [MESH] |Inflammation/immunology/*metabolism [MESH] |Lymph Nodes/immunology [MESH] |Macrophages/*metabolism [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |PPAR gamma/metabolism [MESH] |Receptors, Erythropoietin/metabolism [MESH]Phagocyte respiratory burst activates macrophage erythropoietin signal(epmc).pdf DeepDyve Pubget Overpricing