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Heparan Sulfate in the Developing, Healthy, and Injured Lung #MMPMID26982577
Haeger SM; Yang Y; Schmidt EP
Am J Respir Cell Mol Biol 2016[Jul]; 55 (1): 5-11 PMID26982577show ga
Remarkable progress has been achieved in understanding the regulation of gene expression and protein translation, and how aberrancies in these template-driven processes contribute to disease pathogenesis. However, much of cellular physiology is controlled by non-DNA, nonprotein mediators, such as glycans. The focus of this Translational Review is to highlight the importance of a specific glycan polymer?the glycosaminoglycan heparan sulfate (HS)?on lung health and disease. We demonstrate how HS contributes to lung physiology and pathophysiology via its actions as both a structural constituent of the lung parenchyma as well as a regulator of cellular signaling. By highlighting current uncertainties in HS biology, we identify opportunities for future high-impact pulmonary and critical care translational investigations.