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How does the chemical potential of the substrate drive a uniporter? #MMPMID26807918
Zhang XC; Han L
Protein Sci 2016[Apr]; 25 (4): 933-7 PMID26807918show ga
Uniporters are a large class of transporters mediating facilitated diffusion of substrates along the direction of the substrate concentration gradient. Recently, structures of several important uniporters have been reported; however, the precise mechanisms of uniporter function remain subject of debate. Here, we present a series of general thermodynamic descriptions of uniporters, aimed at understanding the structure?function relationship of uniporters, and in particular to reconcile biochemical phenomena of uniporters with our previously proposed thermodynamic model of general transporters.