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10.1111/bph.13226 http://scihub22266oqcxt.onion/10.1111/bph.13226 C4941127!4941127!26076890     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2016 ; 173 (7): 1116-27 Nephropedia Template TP {{tp|p=26076890|t=2016. Role of the endocannabinoid system in diabetes and diabetic complications |pdf=|usr=}}{{26076890}} gab.com Text Role of the endocannabinoid system in diabetes and diabetic complications JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26076890 #FOAvip Increasing evidence suggests that an overactive endocannabinoid system (ECS) may contribute to the development of diabetes by promoting energy intake and storage, impairing both glucose and lipid metabolism, by exerting pro?apoptotic effects in pancreatic beta cells and by facilitating inflammation in pancreatic islets. Furthermore, hyperglycaemia associated with diabetes has also been implicated in triggering perturbations of the ECS amplifying the pathological processes mentioned above, eventually culminating in a vicious circle. Compelling evidence from preclinical studies indicates that the ECS also influences diabetes?induced oxidative stress, inflammation, fibrosis and subsequent tissue injury in target organs for diabetic complications. In this review, we provide an update on the contribution of the ECS to the pathogenesis of diabetes and diabetic microvascular (retinopathy, nephropathy and neuropathy) and cardiovascular complications. The therapeutic potential of targeting the ECS is also discussed. Linked Articles: This article is part of a themed section on Endocannabinoids. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v173.7/issuetoc Twit Text FOAVip Role of the endocannabinoid system in diabetes and diabetic complications ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26076890 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26076890 #FOAvip English Wikipedia <ref>{{Cite pmid|26076890}}</ref> Role of the endocannabinoid system in diabetes and diabetic complications #MMPMID26076890 Gruden G; Barutta F; Kunos G; Pacher P Br J Pharmacol 2016[Apr]; 173 (7): 1116-27 PMID26076890show ga Increasing evidence suggests that an overactive endocannabinoid system (ECS) may contribute to the development of diabetes by promoting energy intake and storage, impairing both glucose and lipid metabolism, by exerting pro?apoptotic effects in pancreatic beta cells and by facilitating inflammation in pancreatic islets. Furthermore, hyperglycaemia associated with diabetes has also been implicated in triggering perturbations of the ECS amplifying the pathological processes mentioned above, eventually culminating in a vicious circle. Compelling evidence from preclinical studies indicates that the ECS also influences diabetes?induced oxidative stress, inflammation, fibrosis and subsequent tissue injury in target organs for diabetic complications. In this review, we provide an update on the contribution of the ECS to the pathogenesis of diabetes and diabetic microvascular (retinopathy, nephropathy and neuropathy) and cardiovascular complications. The therapeutic potential of targeting the ECS is also discussed. Linked Articles: This article is part of a themed section on Endocannabinoids. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v173.7/issuetoc äRole of the endocannabinoid system in diabetes and diabetic complicati(epmc).pdf DeepDyve Pubget Overpricing