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10.1021/acschembio.6b00130

http://scihub22266oqcxt.onion/10.1021/acschembio.6b00130
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C4941104!4941104!27054264
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suck abstract from ncbi


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pmid27054264      ACS+Chem+Biol 2016 ; 11 (6): 1631-8
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  • Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-?B Transcription Factors #MMPMID27054264
  • Struntz NB; Harki DA
  • ACS Chem Biol 2016[Jun]; 11 (6): 1631-8 PMID27054264show ga
  • Catch and Release DNA Decoys (CRDDs) are a new class of non-natural DNA probes that capture and dissociate from DNA-binding proteins using a light trigger. Photolytic cleavage of non-natural nucleobases in the CRDD yields abasic sites and truncation products that lower the affinity of the CRDD for its protein target. Herein, we demonstrate the ability of the first-generation CRDD to bind and release NF-?B proteins. This platform technology should be applicable to other DNA-binding proteins by modification of the target sequence.
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