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10.1111/nyas.13053 http://scihub22266oqcxt.onion/10.1111/nyas.13053 C4940271!4940271!27153507     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27153507&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+N+Y+Acad+Sci 2016 ; 1374 (1): 52-8 Nephropedia Template TP {{tp|p=27153507|t=2016. Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates |pdf=|usr=}}{{27153507}} gab.com Text Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates JO: Ann N Y Acad Sci http://www.kidney.de/pget.php?&tw=1&pmid=27153507 #FOAvip Current oxime reactivators for organophosphate-inhibited cholinesterase (ChE) do not effectively cross the blood?brain barrier and therefore cannot restore brain ChE activity in vivo. Our laboratories have studied highly relevant sarin and VX surrogates, which differ from their respective nerve agents only in the leaving group and thereby leave ChE phosphylated with the same chemical moiety as sarin and VX. Our laboratories have invented novel substituted phenoxyalkyl pyridinium oximes (U.S. Patent 9,227,937 B2) that lead to reduced ChE inhibition in the brains of rats challenged with a high sublethal dosage of the sarin surrogate, whereas 2-PAM did not, using a paradigm designed to demonstrate brain penetration. In addition, these novel oximes also showed an attenuation of seizure-like behavior compared to rats treated with 2-PAM, giving additional evidence of the ability of these oximes to penetrate the blood?brain barrier. Further, some of these oximes provided 24-hour survival superior to 2-PAM and shortened the duration of seizure-like behavior when rats were challenged with lethal dosages of the sarin and VX surrogates, providing additional support for the concept of these life-saving oximes penetrating the brain. Twit Text FOAVip Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates ????Ann N Y Acad Sci http://www.kidney.de/pget.php?&tw=1&pmid=27153507 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27153507 #FOAvip English Wikipedia <ref>{{Cite pmid|27153507}}</ref> Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates #MMPMID27153507 Chambers JE; Meek EC; Chambers HW Ann N Y Acad Sci 2016[Jun]; 1374 (1): 52-8 PMID27153507show ga Current oxime reactivators for organophosphate-inhibited cholinesterase (ChE) do not effectively cross the blood?brain barrier and therefore cannot restore brain ChE activity in vivo. Our laboratories have studied highly relevant sarin and VX surrogates, which differ from their respective nerve agents only in the leaving group and thereby leave ChE phosphylated with the same chemical moiety as sarin and VX. Our laboratories have invented novel substituted phenoxyalkyl pyridinium oximes (U.S. Patent 9,227,937 B2) that lead to reduced ChE inhibition in the brains of rats challenged with a high sublethal dosage of the sarin surrogate, whereas 2-PAM did not, using a paradigm designed to demonstrate brain penetration. In addition, these novel oximes also showed an attenuation of seizure-like behavior compared to rats treated with 2-PAM, giving additional evidence of the ability of these oximes to penetrate the blood?brain barrier. Further, some of these oximes provided 24-hour survival superior to 2-PAM and shortened the duration of seizure-like behavior when rats were challenged with lethal dosages of the sarin and VX surrogates, providing additional support for the concept of these life-saving oximes penetrating the brain. äNovel brain-penetrating oximes for reactivation of cholinesterase inhi(epmc).pdf DeepDyve Pubget Overpricing