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10.1016/j.clim.2016.04.008 http://scihub22266oqcxt.onion/10.1016/j.clim.2016.04.008 C4940264!4940264!27140729     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2016 ; 168 (ä): 30-6 Nephropedia Template TP {{tp|p=27140729|t=2016. Central role for marginal zone B cells in an animal model of Sjogren?s syndrome? |pdf=|usr=}}{{27140729}} gab.com Text Central role for marginal zone B cells in an animal model of Sjogren s syndrome JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27140729 #FOAvip Patients with Sjogren?s syndrome (SS) have been shown to have abnormal B cell function and increased numbers of marginal zone B cells (MZB and MZB precursors. The current studies utilized the Interleukin 14 alpha transgenic mouse model (IL14aTG) for SS to investigate the roles of marginal zone B cells (MZB) of the innate immune system in the pathophysiology of the disease. Eliminating MZB from IL14aTG mice by B cell specific deletion of RBP-J resulted in complete elimination of all disease manifestations of SS. Mice had normal salivary gland secretions, negative autoantibodies and normal histology of the salivary and lacrimal glands compared to IL14aTG mice at the same time points. In contrast, eliminating B1 cells by deleting btk did not ameliorate the disease. Therefore, MZB are critical for the development of SS. Twit Text FOAVip Central role for marginal zone B cells in an animal model of Sjogren s syndrome ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27140729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27140729 #FOAvip English Wikipedia <ref>{{Cite pmid|27140729}}</ref> Central role for marginal zone B cells in an animal model of Sjogren?s syndrome? #MMPMID27140729 Shen L; Gao C; Suresh L; Xian Z; Song N; Chaves LD; Yu M; Ambrus JL Clin Immunol 2016[Jul]; 168 (ä): 30-6 PMID27140729show ga Patients with Sjogren?s syndrome (SS) have been shown to have abnormal B cell function and increased numbers of marginal zone B cells (MZB and MZB precursors. The current studies utilized the Interleukin 14 alpha transgenic mouse model (IL14aTG) for SS to investigate the roles of marginal zone B cells (MZB) of the innate immune system in the pathophysiology of the disease. Eliminating MZB from IL14aTG mice by B cell specific deletion of RBP-J resulted in complete elimination of all disease manifestations of SS. Mice had normal salivary gland secretions, negative autoantibodies and normal histology of the salivary and lacrimal glands compared to IL14aTG mice at the same time points. In contrast, eliminating B1 cells by deleting btk did not ameliorate the disease. Therefore, MZB are critical for the development of SS. äCentral role for marginal zone B cells in an animal model of Sjogren?s(epmc).pdf DeepDyve Pubget Overpricing