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10.1111/nyas.13015 http://scihub22266oqcxt.onion/10.1111/nyas.13015 C4940262!4940262!26945701     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+N+Y+Acad+Sci 2016 ; 1374 (1): 29-40 Nephropedia Template TP {{tp|p=26945701|t=2016. Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations |pdf=|usr=}}{{26945701}} gab.com Text Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations JO: Ann N Y Acad Sci http://www.kidney.de/pget.php?&tw=1&pmid=26945701 #FOAvip Hydrogen sulfide (H2S) is a chemical hazard in the gas and farming industry. As it is easy to manufacture from common chemicals, it has also become a method of suicide. H2S exerts its toxicity through its high affinity with metallo-proteins, such as cytochrome c oxidase and possibly via its interactions with cysteine residues of various proteins. The latter was recently proposed to acutely alter ion channels with critical implications for cardiac and brain functions. Indeed, during severe H2S intoxication, a coma, associated with a reduction in cardiac contractility, develops within minutes or even seconds leading to death by complete electro-mechanical dissociation of the heart. In addition, long-term neurological deficits can develop due to the direct toxicity of H2S on neurons combined with the consequences of a prolonged apnea and circulatory failure. Here, we review the challenges impeding efforts to offer an effective treatment against H2S intoxication using agents that trap free H2S, and present novel pharmacological approaches aimed at correcting some of the most negative consequences of H2S intoxication. Twit Text FOAVip Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations ????Ann N Y Acad Sci http://www.kidney.de/pget.php?&tw=1&pmid=26945701 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26945701 #FOAvip English Wikipedia <ref>{{Cite pmid|26945701}}</ref> Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations #MMPMID26945701 Haouzi P; Sonobe T; Judenherc-Haouzi A Ann N Y Acad Sci 2016[Jun]; 1374 (1): 29-40 PMID26945701show ga Hydrogen sulfide (H2S) is a chemical hazard in the gas and farming industry. As it is easy to manufacture from common chemicals, it has also become a method of suicide. H2S exerts its toxicity through its high affinity with metallo-proteins, such as cytochrome c oxidase and possibly via its interactions with cysteine residues of various proteins. The latter was recently proposed to acutely alter ion channels with critical implications for cardiac and brain functions. Indeed, during severe H2S intoxication, a coma, associated with a reduction in cardiac contractility, develops within minutes or even seconds leading to death by complete electro-mechanical dissociation of the heart. In addition, long-term neurological deficits can develop due to the direct toxicity of H2S on neurons combined with the consequences of a prolonged apnea and circulatory failure. Here, we review the challenges impeding efforts to offer an effective treatment against H2S intoxication using agents that trap free H2S, and present novel pharmacological approaches aimed at correcting some of the most negative consequences of H2S intoxication. äDeveloping effective countermeasures against acute hydrogen sulfide in(epmc).pdf DeepDyve Pubget Overpricing