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10.1080/15592294.2016.1176649 http://scihub22266oqcxt.onion/10.1080/15592294.2016.1176649 C4939925!4939925!27088311     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epigenetics 2016 ; 11 (6): 426-37 Nephropedia Template TP {{tp|p=27088311|t=2016. Nucleosome positioning changes during human embryonic stem cell differentiation |pdf=|usr=}}{{27088311}} gab.com Text Nucleosome positioning changes during human embryonic stem cell differentiation JO: Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=27088311 #FOAvip Nucleosomes are the basic unit of chromatin. Nucleosome positioning (NP) plays a key role in transcriptional regulation and other biological processes. To better understand NP we used MNase-seq to investigate changes that occur as human embryonic stem cells (hESCs) transition to nascent mesoderm and then to smooth muscle cells (SMCs). Compared to differentiated cell derivatives, nucleosome occupancy at promoters and other notable genic sites, such as exon/intron junctions and adjacent regions, in hESCs shows a stronger correlation with transcript abundance and is less influenced by sequence content. Upon hESC differentiation, genes being silenced, but not genes being activated, display a substantial change in nucleosome occupancy at their promoters. Genome-wide, we detected a shift of NP to regions of higher G+C content as hESCs differentiate to SMCs. Notably, genomic regions with higher nucleosome occupancy harbor twice as many G?C changes but fewer than half A?T changes, compared to regions with lower nucleosome occupancy. Finally, our analysis indicates that the hESC genome is not rearranged and has a sequence mutation rate resembling normal human genomes. Our study reveals another unique feature of hESC chromatin, and sheds light on the relationship between nucleosome occupancy and sequence G+C content. Twit Text FOAVip Nucleosome positioning changes during human embryonic stem cell differentiation ????Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=27088311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27088311 #FOAvip English Wikipedia <ref>{{Cite pmid|27088311}}</ref> Nucleosome positioning changes during human embryonic stem cell differentiation #MMPMID27088311 Zhang W; Li Y; Kulik M; Tiedemann RL; Robertson KD; Dalton S; Zhao S Epigenetics 2016[Jun]; 11 (6): 426-37 PMID27088311show ga Nucleosomes are the basic unit of chromatin. Nucleosome positioning (NP) plays a key role in transcriptional regulation and other biological processes. To better understand NP we used MNase-seq to investigate changes that occur as human embryonic stem cells (hESCs) transition to nascent mesoderm and then to smooth muscle cells (SMCs). Compared to differentiated cell derivatives, nucleosome occupancy at promoters and other notable genic sites, such as exon/intron junctions and adjacent regions, in hESCs shows a stronger correlation with transcript abundance and is less influenced by sequence content. Upon hESC differentiation, genes being silenced, but not genes being activated, display a substantial change in nucleosome occupancy at their promoters. Genome-wide, we detected a shift of NP to regions of higher G+C content as hESCs differentiate to SMCs. Notably, genomic regions with higher nucleosome occupancy harbor twice as many G?C changes but fewer than half A?T changes, compared to regions with lower nucleosome occupancy. Finally, our analysis indicates that the hESC genome is not rearranged and has a sequence mutation rate resembling normal human genomes. Our study reveals another unique feature of hESC chromatin, and sheds light on the relationship between nucleosome occupancy and sequence G+C content. äNucleosome positioning changes during human embryonic stem cell differ(epmc).pdf DeepDyve Pubget Overpricing