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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Expert+Rev+Proteomics 2016 ; 13 (4): 421-33 Nephropedia Template TP
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The current state of the art of quantitative phosphoproteomics and its applications to diabetes research #MMPMID26960075
Chan CYX; Gritsenko MA; Smith RD; Qian WJ
Expert Rev Proteomics 2016[Apr]; 13 (4): 421-33 PMID26960075show ga
Protein phosphorylation is a fundamental regulatory mechanism in many cellular processes and aberrant perturbation of phosphorylation has been implicated in various human diseases. Kinases and their cognate inhibitors have been considered as hotspots for drug development. Therefore, the emerging tools, which enable a system-wide quantitative profiling of phosphoproteome, would offer a powerful impetus in unveiling novel signaling pathways, drug targets and/or biomarkers for diseases of interest. This review highlights recent advances in phosphoproteomics, the current state of the art of the technologies and the challenges and future perspectives of this research area. Finally, some exemplary applications of phosphoproteomics in diabetes research are underscored.