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10.1016/j.stem.2016.06.001 http://scihub22266oqcxt.onion/10.1016/j.stem.2016.06.001 C4938766!4938766!27374788     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Stem+Cell 2016 ; 19 (1): 23-37 Nephropedia Template TP {{tp|p=27374788|t=2016. Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche |pdf=|usr=}}{{27374788}} gab.com Text Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=27374788 #FOAvip Adipose tissue (AT) has previously been identified as an extra-medullary reservoir for normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we show a subpopulation of leukemic stem cells (LSCs) can utilize gonadal adipose tissue (GAT) as a niche to support their metabolism and evade chemotherapy. In a mouse model of blast crisis CML, adipose-resident LSCs exhibit a pro-inflammatory phenotype and induce lipolysis in GAT. GAT lipolysis fuels fatty acid oxidation in LSCs, especially within a subpopulation expressing the fatty acid transporter CD36. CD36+ LSCs have unique metabolic properties, are strikingly enriched in AT, and are protected from chemotherapy by the GAT microenvironment. CD36 also marks a fraction of human blast crisis CML and AML cells with similar biological properties. These findings suggest striking interplay between leukemic cells and adipose tissue to create a unique microenvironment that supports the metabolic demands and survival of a distinct LSC subpopulation. Twit Text FOAVip Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=27374788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27374788 #FOAvip English Wikipedia <ref>{{Cite pmid|27374788}}</ref> Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche #MMPMID27374788 Ye H; Adane B; Khan N; Sullivan T; Minhajuddin M; Gasparetto M; Stevens B; Pei S; Balys M; Ashton JM; Klemm DJ; Woolthuis CM; Stranahan AW; Park CY; Jordan CT Cell Stem Cell 2016[Jul]; 19 (1): 23-37 PMID27374788show ga Adipose tissue (AT) has previously been identified as an extra-medullary reservoir for normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we show a subpopulation of leukemic stem cells (LSCs) can utilize gonadal adipose tissue (GAT) as a niche to support their metabolism and evade chemotherapy. In a mouse model of blast crisis CML, adipose-resident LSCs exhibit a pro-inflammatory phenotype and induce lipolysis in GAT. GAT lipolysis fuels fatty acid oxidation in LSCs, especially within a subpopulation expressing the fatty acid transporter CD36. CD36+ LSCs have unique metabolic properties, are strikingly enriched in AT, and are protected from chemotherapy by the GAT microenvironment. CD36 also marks a fraction of human blast crisis CML and AML cells with similar biological properties. These findings suggest striking interplay between leukemic cells and adipose tissue to create a unique microenvironment that supports the metabolic demands and survival of a distinct LSC subpopulation. äLeukemic stem cells evade chemotherapy by metabolic adaptation to an a(epmc).pdf DeepDyve Pubget Overpricing