Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/nm.4101 http://scihub22266oqcxt.onion/10.1038/nm.4101 C4938755!4938755 !27213816     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27213816 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Med 2016 ; 22 (7 ): 800-6 Nephropedia Template TP {{tp|p=27213816 |t=2016. Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents |pdf=|usr=}}{{27213816 }} gab.com Text Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=27213816 #FOAvip Type 2 diabetes (T2D) is among the most common and costly disorders worldwide. The goal of current medical management for T2D is to transiently ameliorate hyperglycemia through daily dosing of one or more antidiabetic drugs. Hypoglycemia and weight gain are common side effects of therapy, and sustained disease remission is not obtainable with nonsurgical approaches. On the basis of the potent glucose-lowering response elicited by activation of brain fibroblast growth factor (FGF) receptors, we explored the antidiabetic efficacy of centrally administered FGF1, which, unlike other FGF peptides, activates all FGF receptor subtypes. We report that a single intracerebroventricular injection of FGF1 at a dose one-tenth of that needed for antidiabetic efficacy following peripheral injection induces sustained diabetes remission in both mouse and rat models of T2D. This antidiabetic effect is not secondary to weight loss, does not increase the risk of hypoglycemia, and involves a novel and incompletely understood mechanism for increasing glucose clearance from the bloodstream. We conclude that the brain has an inherent potential to induce diabetes remission and that brain FGF receptors are potential pharmacological targets for achieving this goal. Twit Text FOAVip Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=27213816 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27213816 #FOAvip English Wikipedia <ref>{{Cite pmid|27213816 }}</ref> Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents #MMPMID27213816 Scarlett JM ; Rojas JM ; Matsen ME ; Kaiyala KJ ; Stefanovski D ; Bergman RN ; Nguyen HT ; Dorfman MD ; Lantier L ; Wasserman DH ; Mirzadeh Z ; Unterman TG ; Morton GJ ; Schwartz MW Nat Med 2016[Jul]; 22 (7 ): 800-6 PMID27213816 show ga Type 2 diabetes (T2D) is among the most common and costly disorders worldwide. The goal of current medical management for T2D is to transiently ameliorate hyperglycemia through daily dosing of one or more antidiabetic drugs. Hypoglycemia and weight gain are common side effects of therapy, and sustained disease remission is not obtainable with nonsurgical approaches. On the basis of the potent glucose-lowering response elicited by activation of brain fibroblast growth factor (FGF) receptors, we explored the antidiabetic efficacy of centrally administered FGF1, which, unlike other FGF peptides, activates all FGF receptor subtypes. We report that a single intracerebroventricular injection of FGF1 at a dose one-tenth of that needed for antidiabetic efficacy following peripheral injection induces sustained diabetes remission in both mouse and rat models of T2D. This antidiabetic effect is not secondary to weight loss, does not increase the risk of hypoglycemia, and involves a novel and incompletely understood mechanism for increasing glucose clearance from the bloodstream. We conclude that the brain has an inherent potential to induce diabetes remission and that brain FGF receptors are potential pharmacological targets for achieving this goal. |Adipose Tissue/drug effects/metabolism [MESH] |Animals [MESH] |Blood Glucose/*drug effects/metabolism [MESH] |Blotting, Western [MESH] |Body Composition [MESH] |Brain/drug effects/metabolism [MESH] |Carbon Radioisotopes [MESH] |Deoxyglucose [MESH] |Diabetes Mellitus, Experimental/*metabolism [MESH] |Diabetes Mellitus, Type 2/*metabolism [MESH] |Diet, High-Fat [MESH] |Disease Models, Animal [MESH] |Ependymoglial Cells/drug effects/metabolism [MESH] |Fibroblast Growth Factor 1/*pharmacology [MESH] |Forkhead Box Protein O1/genetics [MESH] |Glucose Tolerance Test [MESH] |Heart/drug effects [MESH] |Heat-Shock Proteins/drug effects/metabolism [MESH] |Hyperglycemia/metabolism [MESH] |Hypothalamus/cytology/drug effects/metabolism [MESH] |Injections, Intraventricular [MESH] |Liver/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Mice, Obese [MESH] |Molecular Chaperones [MESH] |Muscle, Skeletal/drug effects/metabolism [MESH] |Myocardium/metabolism [MESH] |Neoplasm Proteins/drug effects/metabolism [MESH] |Proto-Oncogene Proteins c-fos/drug effects/metabolism [MESH] |Rats [MESH] |Rats, Zucker [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Receptor, Insulin/antagonists & inhibitors/genetics [MESH]Central injection of fibroblast growth factor 1 induces sustained remi(epmc).pdf DeepDyve Pubget Overpricing