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10.1080/2162402X.2016.1149674 http://scihub22266oqcxt.onion/10.1080/2162402X.2016.1149674 C4938376!4938376!27471617     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncoimmunology 2016 ; 5 (6): ä Nephropedia Template TP {{tp|p=27471617|t=2016. Trial Watch?Small molecules targeting the immunological tumor microenvironment for cancer therapy |pdf=|usr=}}{{27471617}} gab.com Text Trial Watch Small molecules targeting the immunological tumor microenvironment for cancer therapy JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27471617 #FOAvip Progressing malignancies establish robust immunosuppressive networks that operate both systemically and locally. In particular, as tumors escape immunosurveillance, they recruit increasing amounts of myeloid and lymphoid cells that exert pronounced immunosuppressive effects. These cells not only prevent the natural recognition of growing neoplasms by the immune system, but also inhibit anticancer immune responses elicited by chemo-, radio- and immuno therapeutic interventions. Throughout the past decade, multiple strategies have been devised to counteract the accumulation or activation of tumor-infiltrating immunosuppressive cells for therapeutic purposes. Here, we review recent preclinical and clinical advances on the use of small molecules that target the immunological tumor microenvironment for cancer therapy. These agents include inhibitors of indoleamine 2,3-dioxigenase 1 (IDO1), prostaglandin E2, and specific cytokine receptors, as well as modulators of intratumoral purinergic signaling and arginine metabolism. Twit Text FOAVip Trial Watch Small molecules targeting the immunological tumor microenvironment for cancer therapy ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27471617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27471617 #FOAvip English Wikipedia <ref>{{Cite pmid|27471617}}</ref> Trial Watch?Small molecules targeting the immunological tumor microenvironment for cancer therapy #MMPMID27471617 Buqué A; Bloy N; Aranda F; Cremer I; Eggermont A; Fridman WH; Fucikova J; Galon J; Spisek R; Tartour E; Zitvogel L; Kroemer G; Galluzzi L Oncoimmunology 2016[Jun]; 5 (6): ä PMID27471617show ga Progressing malignancies establish robust immunosuppressive networks that operate both systemically and locally. In particular, as tumors escape immunosurveillance, they recruit increasing amounts of myeloid and lymphoid cells that exert pronounced immunosuppressive effects. These cells not only prevent the natural recognition of growing neoplasms by the immune system, but also inhibit anticancer immune responses elicited by chemo-, radio- and immuno therapeutic interventions. Throughout the past decade, multiple strategies have been devised to counteract the accumulation or activation of tumor-infiltrating immunosuppressive cells for therapeutic purposes. Here, we review recent preclinical and clinical advances on the use of small molecules that target the immunological tumor microenvironment for cancer therapy. These agents include inhibitors of indoleamine 2,3-dioxigenase 1 (IDO1), prostaglandin E2, and specific cytokine receptors, as well as modulators of intratumoral purinergic signaling and arginine metabolism. äTrial Watch?Small molecules targeting the immunological tumor microenv(epmc).pdf DeepDyve Pubget Overpricing