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10.1080/2162402X.2016.1172154 http://scihub22266oqcxt.onion/10.1080/2162402X.2016.1172154 C4938366!4938366!27471651     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncoimmunology 2016 ; 5 (6): ä Nephropedia Template TP {{tp|p=27471651|t=2016. A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation |pdf=|usr=}}{{27471651}} gab.com Text A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27471651 #FOAvip Microenvironmental signals determine the differentiation types and distinct functions of macrophages. Tumor-associated macrophages (TAM) constitute major infiltrates around solid tumor cells and accelerate tumor progression due to their immunosuppressive functions. However, the mechanisms through which tumor microenvironment modulates macrophages transition are not completely elucidated. Hyaluronan (HA), a prominent component in tumor microenvironment, is a notable immunoregulator and its high level is often related to poor prognosis. Herein, we found that the number of M2 macrophages was highly correlated with HA expression in tumor tissues from breast cancer patients. Experimental data showed that breast cancer-derived HA stimulated M2-like TAM formation in a mouse model and had multiple effects on macrophages transformation in vitro, including upregulating CD204, CD206, IL-10 and TGF-?, activating STAT3 signal, and suppressing killing capacity. These data indicate that HA derived from breast cancer activates macrophages in an alternative manner. Further mechanism study revealed that HA-CD44-ERK1/2-STAT3 pathway served as an important regulator in M2-like TAM formation. Therefore, targeting TAM by abrogating HA?CD44 interaction may be a potential strategy for breast cancer immunotherapy. Twit Text FOAVip A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27471651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27471651 #FOAvip English Wikipedia <ref>{{Cite pmid|27471651}}</ref> A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation #MMPMID27471651 Zhang G; Guo L; Yang C; Liu Y; He Y; Du Y; Wang W; Gao F Oncoimmunology 2016[Jun]; 5 (6): ä PMID27471651show ga Microenvironmental signals determine the differentiation types and distinct functions of macrophages. Tumor-associated macrophages (TAM) constitute major infiltrates around solid tumor cells and accelerate tumor progression due to their immunosuppressive functions. However, the mechanisms through which tumor microenvironment modulates macrophages transition are not completely elucidated. Hyaluronan (HA), a prominent component in tumor microenvironment, is a notable immunoregulator and its high level is often related to poor prognosis. Herein, we found that the number of M2 macrophages was highly correlated with HA expression in tumor tissues from breast cancer patients. Experimental data showed that breast cancer-derived HA stimulated M2-like TAM formation in a mouse model and had multiple effects on macrophages transformation in vitro, including upregulating CD204, CD206, IL-10 and TGF-?, activating STAT3 signal, and suppressing killing capacity. These data indicate that HA derived from breast cancer activates macrophages in an alternative manner. Further mechanism study revealed that HA-CD44-ERK1/2-STAT3 pathway served as an important regulator in M2-like TAM formation. Therefore, targeting TAM by abrogating HA?CD44 interaction may be a potential strategy for breast cancer immunotherapy. äA novel role of breast cancer-derived hyaluronan on inducement of M2-l(epmc).pdf DeepDyve Pubget Overpricing