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10.1080/2162402X.2016.1160186 http://scihub22266oqcxt.onion/10.1080/2162402X.2016.1160186 C4938355!4938355!27471632     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncoimmunology 2016 ; 5 (6): ä Nephropedia Template TP {{tp|p=27471632|t=2016. Tumor-infiltrating HLA-matched CD4+ T cells retargeted against Hodgkin and Reed?Sternberg cells |pdf=|usr=}}{{27471632}} gab.com Text Tumor-infiltrating HLA-matched CD4+ T cells retargeted against Hodgkin and Reed Sternberg cells JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27471632 #FOAvip Hodgkin lymphoma (HL) presents with a unique histologic pattern. Pathognomonic Hodgkin and Reed?Sternberg (HRS) cells usually account for less than 1% of the tumor and are embedded in a reactive infiltrate mainly comprised of CD4+ T cells. HRS cells induce an immunosuppressive microenvironment and thereby escape antitumor immunity. To investigate the impact of interactions between HRS cells and T cells, we performed long-term co-culture studies that were further translated into a xenograft model. Surprisingly, we revealed a strong antitumor potential of allogeneic CD4+ T cells against HL cell lines. HRS and CD4+ T cells interact by adhesion complexes similar to immunological synapses. Tumor-cell killing was likely based on the recognition of allogeneic major histocompatibility complex class II (MHC-II) receptor, while CD4+ T cells from MHC-II compatible donors did not develop any antitumor potential in case of HL cell line L428. However, gene expression profiling (GEP) of co-cultured HRS cells as well as tumor infiltration of matched CD4+ T cells indicated cellular interactions. Moreover, matched CD4+ T cells could be activated to kill CD30+ HRS cells when redirected with a CD30-specific chimeric antigen receptor. Our work gives novel insights into the crosstalk between HRS and CD4+ T cells, suggesting the latter as potent effector cells in the adoptive cell therapy of HL. Twit Text FOAVip Tumor-infiltrating HLA-matched CD4+ T cells retargeted against Hodgkin and Reed Sternberg cells ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27471632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27471632 #FOAvip English Wikipedia <ref>{{Cite pmid|27471632}}</ref> Tumor-infiltrating HLA-matched CD4+ T cells retargeted against Hodgkin and Reed?Sternberg cells #MMPMID27471632 Rengstl B; Schmid F; Weiser C; Döring C; Heinrich T; Warner K; Becker PSA; Wistinghausen R; Kameh-Var S; Werling E; Billmeier A; Seidl C; Hartmann S; Abken H; Küppers R; Hansmann ML; Newrzela S Oncoimmunology 2016[Jun]; 5 (6): ä PMID27471632show ga Hodgkin lymphoma (HL) presents with a unique histologic pattern. Pathognomonic Hodgkin and Reed?Sternberg (HRS) cells usually account for less than 1% of the tumor and are embedded in a reactive infiltrate mainly comprised of CD4+ T cells. HRS cells induce an immunosuppressive microenvironment and thereby escape antitumor immunity. To investigate the impact of interactions between HRS cells and T cells, we performed long-term co-culture studies that were further translated into a xenograft model. Surprisingly, we revealed a strong antitumor potential of allogeneic CD4+ T cells against HL cell lines. HRS and CD4+ T cells interact by adhesion complexes similar to immunological synapses. Tumor-cell killing was likely based on the recognition of allogeneic major histocompatibility complex class II (MHC-II) receptor, while CD4+ T cells from MHC-II compatible donors did not develop any antitumor potential in case of HL cell line L428. However, gene expression profiling (GEP) of co-cultured HRS cells as well as tumor infiltration of matched CD4+ T cells indicated cellular interactions. Moreover, matched CD4+ T cells could be activated to kill CD30+ HRS cells when redirected with a CD30-specific chimeric antigen receptor. Our work gives novel insights into the crosstalk between HRS and CD4+ T cells, suggesting the latter as potent effector cells in the adoptive cell therapy of HL. äTumor-infiltrating HLA-matched CD4+ T cells retargeted against Hodgkin(epmc).pdf DeepDyve Pubget Overpricing