Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/imr.12398 http://scihub22266oqcxt.onion/10.1111/imr.12398 C4938245!4938245!27088910     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Rev 2016 ; 271 (1): 114-26 Nephropedia Template TP {{tp|p=27088910|t=2016. T cell selection in the thymus: a spatial and temporal perspective |pdf=|usr=}}{{27088910}} gab.com Text T cell selection in the thymus: a spatial and temporal perspective JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27088910 #FOAvip The ability of T cells to respond to a wide array of foreign antigens while avoiding reactivity to self is largely determined by cellular selection of developing T cells in the thymus. While a great deal is known about the cell types and molecules involved in T cell selection in the thymus, our understanding of the spatial and temporal aspects of this process remain relatively poorly understood. Thymocytes are highly motile within the thymus and travel between specialized microenvironments at different phases of their development while interacting with distinct sets of self-peptides and peptide presenting cells. A knowledge of when, where, and how thymocytes encounter self-peptide MHC ligands at different stages of thymic development is key to understanding T cell selection. In the past several years, our laboratory has investigated this topic using two-photon time-lapse microscopy to directly visualize thymocyte migration and signaling events, together with a living thymic slice preparation to provide a synchronized experimental model of T cell selection in situ. Here, we discuss recent advances in our understanding of the temporal and spatial aspects of T cell selection, highlighting our own work, and placing them in the context of work from other groups. Twit Text FOAVip T cell selection in the thymus: a spatial and temporal perspective ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27088910 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27088910 #FOAvip English Wikipedia <ref>{{Cite pmid|27088910}}</ref> T cell selection in the thymus: a spatial and temporal perspective #MMPMID27088910 Kurd N; Robey EA Immunol Rev 2016[May]; 271 (1): 114-26 PMID27088910show ga The ability of T cells to respond to a wide array of foreign antigens while avoiding reactivity to self is largely determined by cellular selection of developing T cells in the thymus. While a great deal is known about the cell types and molecules involved in T cell selection in the thymus, our understanding of the spatial and temporal aspects of this process remain relatively poorly understood. Thymocytes are highly motile within the thymus and travel between specialized microenvironments at different phases of their development while interacting with distinct sets of self-peptides and peptide presenting cells. A knowledge of when, where, and how thymocytes encounter self-peptide MHC ligands at different stages of thymic development is key to understanding T cell selection. In the past several years, our laboratory has investigated this topic using two-photon time-lapse microscopy to directly visualize thymocyte migration and signaling events, together with a living thymic slice preparation to provide a synchronized experimental model of T cell selection in situ. Here, we discuss recent advances in our understanding of the temporal and spatial aspects of T cell selection, highlighting our own work, and placing them in the context of work from other groups. äT cell selection in the thymus: a spatial and temporal perspective (epmc).pdf DeepDyve Pubget Overpricing