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10.1534/genetics.116.188961 http://scihub22266oqcxt.onion/10.1534/genetics.116.188961 C4937490!4937490!27194749     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genetics 2016 ; 203 (3): 1335-51 Nephropedia Template TP {{tp|p=27194749|t=2016. Epistasis and the Dynamics of Reversion in Molecular Evolution |pdf=|usr=}}{{27194749}} gab.com Text Epistasis and the Dynamics of Reversion in Molecular Evolution JO: Genetics http://www.kidney.de/pget.php?&tw=1&pmid=27194749 #FOAvip Recent studies of protein evolution contend that the longer an amino acid substitution is present at a site, the less likely it is to revert to the amino acid previously occupying that site. Here we study this phenomenon of decreasing reversion rates rigorously and in a much more general context. We show that, under weak mutation and for arbitrary fitness landscapes, reversion rates decrease with time for any site that is involved in at least one epistatic interaction. Specifically, we prove that, at stationarity, the hazard function of the distribution of waiting times until reversion is strictly decreasing for any such site. Thus, in the presence of epistasis, the longer a particular character has been absent from a site, the less likely the site will revert to its prior state. We also explore several examples of this general result, which share a common pattern whereby the probability of having reverted increases rapidly at short times to some substantial value before becoming almost flat after a few substitutions at other sites. This pattern indicates a characteristic tendency for reversion to occur either almost immediately after the initial substitution or only after a very long time. Twit Text FOAVip Epistasis and the Dynamics of Reversion in Molecular Evolution ????Genetics http://www.kidney.de/pget.php?&tw=1&pmid=27194749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27194749 #FOAvip English Wikipedia <ref>{{Cite pmid|27194749}}</ref> Epistasis and the Dynamics of Reversion in Molecular Evolution #MMPMID27194749 McCandlish DM; Shah P; Plotkin JB Genetics 2016[Jul]; 203 (3): 1335-51 PMID27194749show ga Recent studies of protein evolution contend that the longer an amino acid substitution is present at a site, the less likely it is to revert to the amino acid previously occupying that site. Here we study this phenomenon of decreasing reversion rates rigorously and in a much more general context. We show that, under weak mutation and for arbitrary fitness landscapes, reversion rates decrease with time for any site that is involved in at least one epistatic interaction. Specifically, we prove that, at stationarity, the hazard function of the distribution of waiting times until reversion is strictly decreasing for any such site. Thus, in the presence of epistasis, the longer a particular character has been absent from a site, the less likely the site will revert to its prior state. We also explore several examples of this general result, which share a common pattern whereby the probability of having reverted increases rapidly at short times to some substantial value before becoming almost flat after a few substitutions at other sites. This pattern indicates a characteristic tendency for reversion to occur either almost immediately after the initial substitution or only after a very long time. äEpistasis and the Dynamics of Reversion in Molecular Evolution (epmc).pdf DeepDyve Pubget Overpricing