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10.1152/ajprenal.00382.2015 http://scihub22266oqcxt.onion/10.1152/ajprenal.00382.2015 C4935774!4935774!26984953     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2016 ; 310 (11): F1328-36 Nephropedia Template TP {{tp|p=26984953|t=2016. Measuring the intrarenal distribution of glomerular volumes from histological sections |pdf=|usr=}}{{26984953}} gab.com Text Measuring the intrarenal distribution of glomerular volumes from histological sections JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26984953 #FOAvip Glomerular volume is an important metric reflecting glomerular filtration surface area within the kidney. Glomerular hypertrophy, or increased glomerular volume, may be an important marker for renal stress. Current stereological techniques report the average glomerular volume (AVglom) within the kidney. These techniques cannot assess the spatial or regional heterogeneity common in developing renal pathology. Here, we report a novel ?unfolding? technique to measure the actual distribution of individual glomerular volumes in a kidney from the two-dimensional glomerulus profiles observed by optical microscopy. The unfolding technique was first developed and tested for accuracy with simulations and then applied to measure the number of glomeruli (Nglom), AVglom, and intrarenal distribution of individual glomerular volume (IVglom) in the oligosyndactyl (Os/+) mouse model compared with wild-type (WT) controls. The Os/+ mice had fewer and larger glomeruli than WT mice: Nglom was 12,126 ± 1,658 (glomeruli/kidney) in the WT mice and 5,516 ± 899 in the Os/+ mice; AVglom was 2.01 ± 0.28 × 10?4 mm3 for the WT mice and 3.47 ± 0.35 × 10?4 mm3 for the Os/+ mice. Comparing the glomerular volume distributions in Os/+ and WT kidneys, we observed that the Os/+ distribution peaked at a higher value of IVglom than the WT distribution peak, and glomeruli with a radius greater than 55 ?m were more prevalent in the Os/+ mice (3.4 ± 1.6% of total glomeruli vs. 0.6 ± 1.2% in WT). Finally, the largest profiles were more commonly found in the juxtamedullary region. Unfolding is a novel stereological technique that provides a new quantitative view of glomerular volume distribution in the individual kidney. Twit Text FOAVip Measuring the intrarenal distribution of glomerular volumes from histological sections ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26984953 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26984953 #FOAvip English Wikipedia <ref>{{Cite pmid|26984953}}</ref> Measuring the intrarenal distribution of glomerular volumes from histological sections #MMPMID26984953 Hann BD; Baldelomar EJ; Charlton JR; Bennett KM Am J Physiol Renal Physiol 2016[Jun]; 310 (11): F1328-36 PMID26984953show ga Glomerular volume is an important metric reflecting glomerular filtration surface area within the kidney. Glomerular hypertrophy, or increased glomerular volume, may be an important marker for renal stress. Current stereological techniques report the average glomerular volume (AVglom) within the kidney. These techniques cannot assess the spatial or regional heterogeneity common in developing renal pathology. Here, we report a novel ?unfolding? technique to measure the actual distribution of individual glomerular volumes in a kidney from the two-dimensional glomerulus profiles observed by optical microscopy. The unfolding technique was first developed and tested for accuracy with simulations and then applied to measure the number of glomeruli (Nglom), AVglom, and intrarenal distribution of individual glomerular volume (IVglom) in the oligosyndactyl (Os/+) mouse model compared with wild-type (WT) controls. The Os/+ mice had fewer and larger glomeruli than WT mice: Nglom was 12,126 ± 1,658 (glomeruli/kidney) in the WT mice and 5,516 ± 899 in the Os/+ mice; AVglom was 2.01 ± 0.28 × 10?4 mm3 for the WT mice and 3.47 ± 0.35 × 10?4 mm3 for the Os/+ mice. Comparing the glomerular volume distributions in Os/+ and WT kidneys, we observed that the Os/+ distribution peaked at a higher value of IVglom than the WT distribution peak, and glomeruli with a radius greater than 55 ?m were more prevalent in the Os/+ mice (3.4 ± 1.6% of total glomeruli vs. 0.6 ± 1.2% in WT). Finally, the largest profiles were more commonly found in the juxtamedullary region. Unfolding is a novel stereological technique that provides a new quantitative view of glomerular volume distribution in the individual kidney. äMeasuring the intrarenal distribution of glomerular volumes from histo(epmc).pdf DeepDyve Pubget Overpricing