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10.1152/ajpendo.00121.2016 http://scihub22266oqcxt.onion/10.1152/ajpendo.00121.2016 C4935144!4935144 !27166282     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27166282 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Endocrinol+Metab 2016 ; 310 (11 ): E994-E1002 Nephropedia Template TP {{tp|p=27166282 |t=2016. Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis |pdf=|usr=}}{{27166282 }} gab.com Text Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis JO: Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=27166282 #FOAvip Mammalian or mechanistic target of rapamycin (mTOR) senses nutrient, energy, and hormone signals to regulate metabolism and energy homeostasis. mTOR activity in the hypothalamus, which is associated with changes in energy status, plays a critical role in the regulation of food intake and body weight. mTOR integrates signals from a variety of "energy balancing" hormones such as leptin, insulin, and ghrelin, although its action varies in response to these distinct hormonal stimuli as well as across different neuronal populations. In this review, we summarize and highlight recent findings regarding the functional roles of mTOR complex 1 (mTORC1) in the hypothalamus specifically in its regulation of body weight, energy expenditure, and glucose/lipid homeostasis. Understanding the role and underlying mechanisms behind mTOR-related signaling in the brain will undoubtedly pave new avenues for future therapeutics and interventions that can combat obesity, insulin resistance, and diabetes. Twit Text FOAVip Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis ????Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=27166282 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27166282 #FOAvip English Wikipedia <ref>{{Cite pmid|27166282 }}</ref> Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis #MMPMID27166282 Hu F ; Xu Y ; Liu F Am J Physiol Endocrinol Metab 2016[Jun]; 310 (11 ): E994-E1002 PMID27166282 show ga Mammalian or mechanistic target of rapamycin (mTOR) senses nutrient, energy, and hormone signals to regulate metabolism and energy homeostasis. mTOR activity in the hypothalamus, which is associated with changes in energy status, plays a critical role in the regulation of food intake and body weight. mTOR integrates signals from a variety of "energy balancing" hormones such as leptin, insulin, and ghrelin, although its action varies in response to these distinct hormonal stimuli as well as across different neuronal populations. In this review, we summarize and highlight recent findings regarding the functional roles of mTOR complex 1 (mTORC1) in the hypothalamus specifically in its regulation of body weight, energy expenditure, and glucose/lipid homeostasis. Understanding the role and underlying mechanisms behind mTOR-related signaling in the brain will undoubtedly pave new avenues for future therapeutics and interventions that can combat obesity, insulin resistance, and diabetes. |Animals [MESH] |Body Weight/physiology [MESH] |Eating/*physiology [MESH] |Energy Metabolism/*physiology [MESH] |Feedback, Physiological/physiology [MESH] |Homeostasis/*physiology [MESH] |Hormones/*metabolism [MESH] |Humans [MESH] |Hypothalamus/*physiology [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Multiprotein Complexes/*metabolism [MESH] |Signal Transduction/physiology [MESH] |Systems Integration [MESH]Hypothalamic roles of mTOR complex I: integration of nutrient and horm(epmc).pdf DeepDyve Pubget Overpricing