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10.1038/nature17436 http://scihub22266oqcxt.onion/10.1038/nature17436 C4935084!4935084!27074511     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2016 ; 532 (7599): 385-8 Nephropedia Template TP {{tp|p=27074511|t=2016. The diversity-generating benefits of a prokaryotic adaptive immune system |pdf=|usr=}}{{27074511}} gab.com Text The diversity-generating benefits of a prokaryotic adaptive immune system JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=27074511 #FOAvip Prokaryotic CRISPR-Cas adaptive immune systems insert spacers derived from viruses and other parasitic DNA elements into CRISPR loci to provide sequence-specific immunity1,2. This frequently results in high within-population spacer diversity3?6, but it is unclear if and why this is important. Here we show that, as a result of this spacer diversity, viruses can no longer evolve to overcome CRISPR-Cas by point mutation, which results in rapid virus extinction. This effect arises from synergy between spacer diversity and the high specificity of infection, which greatly increases overall population resistance. We propose that the resulting short-lived nature of CRISPR-dependent bacteria?virus coevolution has provided strong selection for the evolution of sophisticated virus-encoded anti-CRISPR mechanisms7. Twit Text FOAVip The diversity-generating benefits of a prokaryotic adaptive immune system ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=27074511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27074511 #FOAvip English Wikipedia <ref>{{Cite pmid|27074511}}</ref> The diversity-generating benefits of a prokaryotic adaptive immune system #MMPMID27074511 van Houte S; Ekroth AKE; Broniewski JM; Chabas H; Ashby B; Bondy-Denomy J; Gandon S; Boots M; Paterson S; Buckling A; Westra ER Nature 2016[Apr]; 532 (7599): 385-8 PMID27074511show ga Prokaryotic CRISPR-Cas adaptive immune systems insert spacers derived from viruses and other parasitic DNA elements into CRISPR loci to provide sequence-specific immunity1,2. This frequently results in high within-population spacer diversity3?6, but it is unclear if and why this is important. Here we show that, as a result of this spacer diversity, viruses can no longer evolve to overcome CRISPR-Cas by point mutation, which results in rapid virus extinction. This effect arises from synergy between spacer diversity and the high specificity of infection, which greatly increases overall population resistance. We propose that the resulting short-lived nature of CRISPR-dependent bacteria?virus coevolution has provided strong selection for the evolution of sophisticated virus-encoded anti-CRISPR mechanisms7. äThe diversity-generating benefits of a prokaryotic adaptive immune sys(epmc).pdf DeepDyve Pubget Overpricing