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10.1074/jbc.M116.723551 http://scihub22266oqcxt.onion/10.1074/jbc.M116.723551 C4933188!4933188 !27226587     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27226587 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2016 ; 291 (27 ): 14356-14362 Nephropedia Template TP {{tp|p=27226587 |t=2016. Reprogramming Nurse-like Cells with Interferon ? to Interrupt Chronic Lymphocytic Leukemia Cell Survival |pdf=|usr=}}{{27226587 }} gab.com Text Reprogramming Nurse-like Cells with Interferon to Interrupt Chronic Lymphocytic Leukemia Cell Survival JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27226587 #FOAvip Nurse-like cells (NLCs) play a central role in chronic lymphocytic leukemia (CLL) because they promote the survival and proliferation of CLL cells. NLCs are derived from the monocyte lineage and are driven toward their phenotype via contact-dependent and -independent signals from CLL cells. Because of the central role of NLCs in promoting disease, new strategies to eliminate or reprogram them are needed. Successful reprogramming may be of extra benefit because NLCs express Fc? receptors (Fc?Rs) and thus could act as effector cells within the context of antibody therapy. IFN? is known to promote the polarization of macrophages toward an M1-like state that is no longer tumor-supportive. In an effort to reprogram the phenotype of NLCs, we found that IFN? up-regulated the M1-related markers CD86 and HLA-DR as well as Fc?RIa. This corresponded to enhanced Fc?R-mediated cytokine production as well as rituximab-mediated phagocytosis of CLL cells. In addition, IFN? down-regulated the expression of CD31, resulting in withdrawal of the survival advantage on CLL cells. These results suggest that IFN? can re-educate NLCs and shift them toward an effector-like state and that therapies promoting local IFN? production may be effective adjuvants for antibody therapy in CLL. Twit Text FOAVip Reprogramming Nurse-like Cells with Interferon to Interrupt Chronic Lymphocytic Leukemia Cell Survival ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27226587 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27226587 #FOAvip English Wikipedia <ref>{{Cite pmid|27226587 }}</ref> Reprogramming Nurse-like Cells with Interferon ? to Interrupt Chronic Lymphocytic Leukemia Cell Survival #MMPMID27226587 Gautam S ; Fatehchand K ; Elavazhagan S ; Reader BF ; Ren L ; Mo X ; Byrd JC ; Tridandapani S ; Butchar JP J Biol Chem 2016[Jul]; 291 (27 ): 14356-14362 PMID27226587 show ga Nurse-like cells (NLCs) play a central role in chronic lymphocytic leukemia (CLL) because they promote the survival and proliferation of CLL cells. NLCs are derived from the monocyte lineage and are driven toward their phenotype via contact-dependent and -independent signals from CLL cells. Because of the central role of NLCs in promoting disease, new strategies to eliminate or reprogram them are needed. Successful reprogramming may be of extra benefit because NLCs express Fc? receptors (Fc?Rs) and thus could act as effector cells within the context of antibody therapy. IFN? is known to promote the polarization of macrophages toward an M1-like state that is no longer tumor-supportive. In an effort to reprogram the phenotype of NLCs, we found that IFN? up-regulated the M1-related markers CD86 and HLA-DR as well as Fc?RIa. This corresponded to enhanced Fc?R-mediated cytokine production as well as rituximab-mediated phagocytosis of CLL cells. In addition, IFN? down-regulated the expression of CD31, resulting in withdrawal of the survival advantage on CLL cells. These results suggest that IFN? can re-educate NLCs and shift them toward an effector-like state and that therapies promoting local IFN? production may be effective adjuvants for antibody therapy in CLL. |*Cell Survival [MESH] |B7-2 Antigen/metabolism [MESH] |Cells, Cultured [MESH] |HLA-DR Antigens/metabolism [MESH] |Humans [MESH] |Interferon-gamma/*administration & dosage [MESH] |Leukemia, Lymphocytic, Chronic, B-Cell/metabolism/*pathology [MESH] |Phagocytosis [MESH]Reprogramming Nurse-like Cells with Interferon ? to Interrupt Chronic (epmc).pdf DeepDyve Pubget Overpricing