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10.1074/jbc.M115.685792 http://scihub22266oqcxt.onion/10.1074/jbc.M115.685792 C4933182!4933182 !27189937     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27189937 &cmd=llinks): Failed to open stream: HTTP request failed! 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Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels |pdf=|usr=}}{{27189937 }} gab.com Text Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27189937 #FOAvip Metabolic reprogramming is emerging as a hallmark of the innate immune response, and the dynamic control of metabolites such as succinate serves to facilitate the execution of inflammatory responses in macrophages and other immune cells. Immunoresponsive gene 1 (Irg1) expression is induced by inflammatory stimuli, and its enzyme product cis-aconitate decarboxylase catalyzes the production of itaconate from the tricarboxylic acid cycle. Here we identify an immunometabolic regulatory pathway that links Irg1 and itaconate production to the succinate accumulation that occurs in the context of innate immune responses. Itaconate levels and Irg1 expression correlate strongly with succinate during LPS exposure in macrophages and non-immune cells. We demonstrate that itaconate acts as an endogenous succinate dehydrogenase inhibitor to cause succinate accumulation. Loss of itaconate production in activated macrophages from Irg1(-/-) mice decreases the accumulation of succinate in response to LPS exposure. This metabolic network links the innate immune response and tricarboxylic acid metabolism to function of the electron transport chain. Twit Text FOAVip Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27189937 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27189937 #FOAvip English Wikipedia <ref>{{Cite pmid|27189937 }}</ref> Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels #MMPMID27189937 Cordes T ; Wallace M ; Michelucci A ; Divakaruni AS ; Sapcariu SC ; Sousa C ; Koseki H ; Cabrales P ; Murphy AN ; Hiller K ; Metallo CM J Biol Chem 2016[Jul]; 291 (27 ): 14274-14284 PMID27189937 show ga Metabolic reprogramming is emerging as a hallmark of the innate immune response, and the dynamic control of metabolites such as succinate serves to facilitate the execution of inflammatory responses in macrophages and other immune cells. Immunoresponsive gene 1 (Irg1) expression is induced by inflammatory stimuli, and its enzyme product cis-aconitate decarboxylase catalyzes the production of itaconate from the tricarboxylic acid cycle. Here we identify an immunometabolic regulatory pathway that links Irg1 and itaconate production to the succinate accumulation that occurs in the context of innate immune responses. Itaconate levels and Irg1 expression correlate strongly with succinate during LPS exposure in macrophages and non-immune cells. We demonstrate that itaconate acts as an endogenous succinate dehydrogenase inhibitor to cause succinate accumulation. Loss of itaconate production in activated macrophages from Irg1(-/-) mice decreases the accumulation of succinate in response to LPS exposure. This metabolic network links the innate immune response and tricarboxylic acid metabolism to function of the electron transport chain. |Animals [MESH] |Cell Line [MESH] |Hydro-Lyases/*physiology [MESH] |Lipopolysaccharides/pharmacology [MESH] |Macrophages/drug effects/metabolism [MESH] |Mice [MESH] |Succinate Dehydrogenase/*antagonists & inhibitors [MESH] |Succinates/*pharmacology [MESH]Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase (epmc).pdf DeepDyve Pubget Overpricing