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10.1074/jbc.M115.695866 http://scihub22266oqcxt.onion/10.1074/jbc.M115.695866 C4933157!4933157 !27226531     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27226531 &cmd=llinks): Failed to open stream: HTTP request failed! 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Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity |pdf=|usr=}}{{27226531 }} gab.com Text Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27226531 #FOAvip Emerging antibiotic resistance among pathogenic bacteria is an issue of great clinical importance, and new approaches to therapy are urgently needed. Anacardic acid, the primary active component of cashew nut shell extract, is a natural product used in the treatment of a variety of medical conditions, including infectious abscesses. Here, we investigate the effects of this natural product on the function of human neutrophils. We find that anacardic acid stimulates the production of reactive oxygen species and neutrophil extracellular traps, two mechanisms utilized by neutrophils to kill invading bacteria. Molecular modeling and pharmacological inhibitor studies suggest anacardic acid stimulation of neutrophils occurs in a PI3K-dependent manner through activation of surface-expressed G protein-coupled sphingosine-1-phosphate receptors. Neutrophil extracellular traps produced in response to anacardic acid are bactericidal and complement select direct antimicrobial activities of the compound. Twit Text FOAVip Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27226531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27226531 #FOAvip English Wikipedia <ref>{{Cite pmid|27226531 }}</ref> Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity #MMPMID27226531 Hollands A ; Corriden R ; Gysler G ; Dahesh S ; Olson J ; Raza Ali S ; Kunkel MT ; Lin AE ; Forli S ; Newton AC ; Kumar GB ; Nair BG ; Perry JJP ; Nizet V J Biol Chem 2016[Jul]; 291 (27 ): 13964-13973 PMID27226531 show ga Emerging antibiotic resistance among pathogenic bacteria is an issue of great clinical importance, and new approaches to therapy are urgently needed. Anacardic acid, the primary active component of cashew nut shell extract, is a natural product used in the treatment of a variety of medical conditions, including infectious abscesses. Here, we investigate the effects of this natural product on the function of human neutrophils. We find that anacardic acid stimulates the production of reactive oxygen species and neutrophil extracellular traps, two mechanisms utilized by neutrophils to kill invading bacteria. Molecular modeling and pharmacological inhibitor studies suggest anacardic acid stimulation of neutrophils occurs in a PI3K-dependent manner through activation of surface-expressed G protein-coupled sphingosine-1-phosphate receptors. Neutrophil extracellular traps produced in response to anacardic acid are bactericidal and complement select direct antimicrobial activities of the compound. |Anacardic Acids/*pharmacology [MESH] |Anacardium/*chemistry [MESH] |Anti-Bacterial Agents/*pharmacology [MESH] |Extracellular Traps/*metabolism [MESH] |Humans [MESH] |Lysophospholipids/metabolism [MESH] |Neutrophils/*drug effects [MESH] |Respiratory Burst [MESH]Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutr(epmc).pdf DeepDyve Pubget Overpricing