Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.15252/embj.201593458 http://scihub22266oqcxt.onion/10.15252/embj.201593458 C4931188!4931188 !27234299     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27234299 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27234299 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2016 ; 35 (13 ): 1385-99 Nephropedia Template TP {{tp|p=27234299 |t=2016. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression |pdf=|usr=}}{{27234299 }} gab.com Text HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=27234299 #FOAvip Herpes simplex virus (HSV) 1 stimulates type I IFN expression through the cGAS-STING-TBK1 signaling axis. Macrophages have recently been proposed to be an essential source of IFN during viral infection. However, it is not known how HSV-1 inhibits IFN expression in this cell type. Here, we show that HSV-1 inhibits type I IFN induction through the cGAS-STING-TBK1 pathway in human macrophages, in a manner dependent on the conserved herpesvirus protein ICP27. This viral protein was expressed de novo in macrophages with early nuclear localization followed by later translocation to the cytoplasm where ICP27 prevented activation of IRF3. ICP27 interacted with TBK1 and STING in a manner that was dependent on TBK1 activity and the RGG motif in ICP27. Thus, HSV-1 inhibits expression of type I IFN in human macrophages through ICP27-dependent targeting of the TBK1-activated STING signalsome. Twit Text FOAVip HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=27234299 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27234299 #FOAvip English Wikipedia <ref>{{Cite pmid|27234299 }}</ref> HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression #MMPMID27234299 Christensen MH ; Jensen SB ; Miettinen JJ ; Luecke S ; Prabakaran T ; Reinert LS ; Mettenleiter T ; Chen ZJ ; Knipe DM ; Sandri-Goldin RM ; Enquist LW ; Hartmann R ; Mogensen TH ; Rice SA ; Nyman TA ; Matikainen S ; Paludan SR EMBO J 2016[Jul]; 35 (13 ): 1385-99 PMID27234299 show ga Herpes simplex virus (HSV) 1 stimulates type I IFN expression through the cGAS-STING-TBK1 signaling axis. Macrophages have recently been proposed to be an essential source of IFN during viral infection. However, it is not known how HSV-1 inhibits IFN expression in this cell type. Here, we show that HSV-1 inhibits type I IFN induction through the cGAS-STING-TBK1 pathway in human macrophages, in a manner dependent on the conserved herpesvirus protein ICP27. This viral protein was expressed de novo in macrophages with early nuclear localization followed by later translocation to the cytoplasm where ICP27 prevented activation of IRF3. ICP27 interacted with TBK1 and STING in a manner that was dependent on TBK1 activity and the RGG motif in ICP27. Thus, HSV-1 inhibits expression of type I IFN in human macrophages through ICP27-dependent targeting of the TBK1-activated STING signalsome. |*Immune Evasion [MESH] |Cells, Cultured [MESH] |Herpesvirus 1, Human/*pathogenicity [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Immediate-Early Proteins/*metabolism [MESH] |Interferon Type I/*antagonists & inhibitors [MESH] |Macrophages/*immunology [MESH] |Membrane Proteins/*metabolism [MESH] |Protein Interaction Mapping [MESH]HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit vir(epmc).pdf DeepDyve Pubget Overpricing