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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cold+Spring+Harb+Perspect+Biol 2016 ; 8 (7): ä Nephropedia Template TP
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Activins and Inhibins: Roles in Development, Physiology, and Disease #MMPMID27328872
Namwanje M; Brown CW
Cold Spring Harb Perspect Biol 2016[Jul]; 8 (7): ä PMID27328872show ga
Since their original discovery as regulators of follicle-stimulating hormone (FSH) secretion and erythropoiesis, the TGF-? family members activin and inhibin have been shown to participate in a variety of biological processes, from the earliest stages of embryonic development to highly specialized functions in terminally differentiated cells and tissues. Herein, we present the history, structures, signaling mechanisms, regulation, and biological processes in which activins and inhibins participate, including several recently discovered biological activities and functional antagonists. The potential therapeutic relevance of these advances is also discussed.