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10.1101/cshperspect.a026237 http://scihub22266oqcxt.onion/10.1101/cshperspect.a026237 C4930919!4930919!27371671     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Med 2016 ; 6 (7): ä Nephropedia Template TP {{tp|p=27371671|t=2016. MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond |pdf=|usr=}}{{27371671}} gab.com Text MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=27371671 #FOAvip The MDMX protein was identified as a p53-interacting protein with a strong similarity to MDM2. Like Mdm2, Mdmx expression is essential for curbing p53 activity during embryonic development, indicating nonredundant functions of Mdmx and Mdm2. There is now a large body of evidence indicating that cancers frequently up-regulate MDMX expression as a means to dampen p53 tumor-suppressor function. Importantly, MDMX also shows p53-independent oncogenic functions. These data make MDMX an attractive therapeutic target for cancer therapy. Here, we summarize the mechanisms used by cancer cells to increase MDMX expression and promising pharmacological strategies to target MDMX in cancer?in particular, the recent findings that antisense oligonucleotides (ASOs) can be used to efficiently modulate MDMX messenger RNA (mRNA) splicing. Twit Text FOAVip MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=27371671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27371671 #FOAvip English Wikipedia <ref>{{Cite pmid|27371671}}</ref> MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond #MMPMID27371671 Marine JC; Jochemsen AG Cold Spring Harb Perspect Med 2016[Jul]; 6 (7): ä PMID27371671show ga The MDMX protein was identified as a p53-interacting protein with a strong similarity to MDM2. Like Mdm2, Mdmx expression is essential for curbing p53 activity during embryonic development, indicating nonredundant functions of Mdmx and Mdm2. There is now a large body of evidence indicating that cancers frequently up-regulate MDMX expression as a means to dampen p53 tumor-suppressor function. Importantly, MDMX also shows p53-independent oncogenic functions. These data make MDMX an attractive therapeutic target for cancer therapy. Here, we summarize the mechanisms used by cancer cells to increase MDMX expression and promising pharmacological strategies to target MDMX in cancer?in particular, the recent findings that antisense oligonucleotides (ASOs) can be used to efficiently modulate MDMX messenger RNA (mRNA) splicing. äMDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyon(epmc).pdf DeepDyve Pubget Overpricing