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10.1158/0008-5472.CAN-16-0359 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-0359 C4930690!4930690!27325641     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2016 ; 76 (13): 3666-70 Nephropedia Template TP {{tp|p=27325641|t=2016. OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer |pdf=|usr=}}{{27325641}} gab.com Text OncomiR or Tumor Suppressor The Duplicity of MicroRNAs in Cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27325641 #FOAvip MicroRNAs are short, noncoding RNAs whose dysregulation has been implicated in most, if not all, cancers. They regulate gene expression by suppressing mRNA translation and reducing mRNA stability. To this end, there is a great deal of interest in modifying miRNA expression levels for the treatment of cancer. However, the literature is fraught with inconsistent accounts as to whether various miRNAs are oncogenic or tumor suppressive. In this review, we directly examine these inconsistencies and propose several mechanisms to explain them. These mechanisms include the possibility that specific miRNAs can simultaneously produce competing oncogenic and tumor suppressive effects by suppressing both tumor suppressive mRNAs and oncogenic mRNAs, respectively. In addition, miRNAs can modulate tumor-modifying extrinsic factors, such as cancer-immune system interactions, stromal cell interactions, oncoviruses, and sensitivity to therapy. Ultimately, it is the balance between these processes which determines whether a specific miRNA produces a net oncogenic or net tumor suppressive effect. A solid understanding of this phenomenon will likely prove valuable in evaluating miRNA targets for cancer therapy. Twit Text FOAVip OncomiR or Tumor Suppressor The Duplicity of MicroRNAs in Cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27325641 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27325641 #FOAvip English Wikipedia <ref>{{Cite pmid|27325641}}</ref> OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer #MMPMID27325641 Svoronos AA; Engelman DM; Slack FJ Cancer Res 2016[Jul]; 76 (13): 3666-70 PMID27325641show ga MicroRNAs are short, noncoding RNAs whose dysregulation has been implicated in most, if not all, cancers. They regulate gene expression by suppressing mRNA translation and reducing mRNA stability. To this end, there is a great deal of interest in modifying miRNA expression levels for the treatment of cancer. However, the literature is fraught with inconsistent accounts as to whether various miRNAs are oncogenic or tumor suppressive. In this review, we directly examine these inconsistencies and propose several mechanisms to explain them. These mechanisms include the possibility that specific miRNAs can simultaneously produce competing oncogenic and tumor suppressive effects by suppressing both tumor suppressive mRNAs and oncogenic mRNAs, respectively. In addition, miRNAs can modulate tumor-modifying extrinsic factors, such as cancer-immune system interactions, stromal cell interactions, oncoviruses, and sensitivity to therapy. Ultimately, it is the balance between these processes which determines whether a specific miRNA produces a net oncogenic or net tumor suppressive effect. A solid understanding of this phenomenon will likely prove valuable in evaluating miRNA targets for cancer therapy. äOncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer (epmc).pdf DeepDyve Pubget Overpricing