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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Biochem+Sci 2016 ; 41 (7): 578-94 Nephropedia Template TP
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The APOBEC Protein Family: United by Structure, Divergent in Function #MMPMID27283515
Salter JD; Bennett RP; Smith HC
Trends Biochem Sci 2016[Jul]; 41 (7): 578-94 PMID27283515show ga
The APOBEC (Apolipoprotein B mRNA Editing Catalytic Polypeptide-like) family of proteins has diverse and important functions in human health and disease. These proteins have an intrinsic ability to bind to both RNA and single-stranded (ss)DNA. Both function and tissue-specific expression varies widely for each APOBEC protein. We are beginning to understand that the activity of APOBEC proteins is regulated through genetic alterations, changes in their transcription and mRNA processing, and through their interactions with other macromolecules in the cell. Loss of cellular control of APOBEC activities leads to DNA hypermutation and promiscuous RNA editing associated with the development of cancer or viral drug resistance, underscoring the importance of understanding how APOBEC proteins are regulated.