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10.1016/j.tibs.2016.04.005 http://scihub22266oqcxt.onion/10.1016/j.tibs.2016.04.005 C4930368!4930368!27174209     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Biochem+Sci 2016 ; 41 (7): 621-32 Nephropedia Template TP {{tp|p=27174209|t=2016. Biochemical Basis Underlying Sestrins? Physiological Activities |pdf=|usr=}}{{27174209}} gab.com Text Biochemical Basis Underlying Sestrins Physiological Activities JO: Trends Biochem Sci http://www.kidney.de/pget.php?&tw=1&pmid=27174209 #FOAvip Excessive accumulation of reactive oxygen species (ROS) and chronic activation of mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) are well-characterized promoters of aging and age-associated degenerative pathologies. Sestrins, a family of highly conserved stress-inducible proteins, are important negative regulators of both ROS and mTORC1 signaling pathways; however, the mechanistic basis of how Sestrins suppress these pathways remains elusive. In the past couple of years, breakthrough discoveries about Sestrin signaling and its molecular nature have deeply heightened our biochemical understanding of Sestrin function. These discoveries have also uncovered new potential therapeutic strategies that may eventually enable us to attenuate aging and age-associated diseases. Twit Text FOAVip Biochemical Basis Underlying Sestrins Physiological Activities ????Trends Biochem Sci http://www.kidney.de/pget.php?&tw=1&pmid=27174209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27174209 #FOAvip English Wikipedia <ref>{{Cite pmid|27174209}}</ref> Biochemical Basis Underlying Sestrins? Physiological Activities #MMPMID27174209 Ho A; Cho CS; Namkoong S; Cho US; Lee JH Trends Biochem Sci 2016[Jul]; 41 (7): 621-32 PMID27174209show ga Excessive accumulation of reactive oxygen species (ROS) and chronic activation of mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) are well-characterized promoters of aging and age-associated degenerative pathologies. Sestrins, a family of highly conserved stress-inducible proteins, are important negative regulators of both ROS and mTORC1 signaling pathways; however, the mechanistic basis of how Sestrins suppress these pathways remains elusive. In the past couple of years, breakthrough discoveries about Sestrin signaling and its molecular nature have deeply heightened our biochemical understanding of Sestrin function. These discoveries have also uncovered new potential therapeutic strategies that may eventually enable us to attenuate aging and age-associated diseases. äBiochemical Basis Underlying Sestrins? Physiological Activities (epmc).pdf DeepDyve Pubget Overpricing