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Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Pharmacoepidemiol+Drug+Saf 2016 ; 25 (4): 453-61 Nephropedia Template TP
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Evaluation of Propensity Scores, Disease Risk Scores, and Regression in Confounder Adjustment for the Safety of Emerging Treatment with Group Sequential Monitoring #MMPMID26875591
Xu S; Shetterly S; Cook AJ; Raebel MA; Goonesekera S; Shoaibi A; Roy J; Fireman B
Pharmacoepidemiol Drug Saf 2016[Apr]; 25 (4): 453-61 PMID26875591show ga
Purpose: The objective of this study is to evaluate regression, matching and stratification on propensity score (PS) or disease risk score (DRS) in a setting of sequential analyses where statistical hypotheses are tested multiple times. Methods: In a setting of sequential analyses, we simulated incident users and binary outcomes with different confounding strength, outcome incidence, and the adoption rate of treatment. We compared type I error rate, empirical power, and time to signal using the following confounder adjustments: 1) regression; 2) treatment matching (1:1, 1:4) on PS or DRS, and 3) stratification on PS or DRS. We estimated PS and DRS using lookwise and cumulative methods (all data up to the current look). We applied these confounder adjustments in examining the association between NSAIDS and bleeding. Results: PS and DRS methods had similar empirical power and time to signal. However DRS methods yielded type I error rates up to 17% for 1:4 matching and 15.3% for stratification methods when treatment and outcome were common and confounding strength with treatment was stronger. When treatment and outcome were not common, stratification on PS and DRS and regression yielded 8?10% type I error rates and inflated empirical power. However when outcome and treatment were common both regression and stratification on PS outperformed other matching methods with type I error rates close to 5%. Conclusions: We suggest regression and stratification on PS when the outcomes and/or treatment is common, and use of matching on PS with higher ratios when outcome or treatment are rare or moderately rare.