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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cereb+Blood+Flow+Metab
2016 ; 36
(7
): 1157-64
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Still cooling after all these years: Meta-analysis of pre-clinical trials of
therapeutic hypothermia for acute ischemic stroke
#MMPMID27089911
Dumitrascu OM
; Lamb J
; Lyden PD
J Cereb Blood Flow Metab
2016[Jul]; 36
(7
): 1157-64
PMID27089911
show ga
Therapeutic hypothermia is the most potent neuroprotectant for experimental
cerebral ischemia, illustrated in a 2007 meta-analysis published in this journal.
To address recent therapeutic nihilism, we systematically reviewed recent
experimental literature. Quality scoring showed considerable improvement in study
design. Using several outcome measures in a variety of models and species,
therapeutic hypothermia was protective compared with normothermia, with powerful
and statistically significant normalized treatment effect sizes, in 60 papers
comprising 216 comparisons. In the past 5 years, preclinical studies of ischemic
stroke re-emphasize that therapeutic hypothermia is potently effective,
justifying further development in larger human clinical trials.