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10.1177/0271678X16645112

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suck abstract from ncbi


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pmid27089911
      J+Cereb+Blood+Flow+Metab 2016 ; 36 (7 ): 1157-64
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  • Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke #MMPMID27089911
  • Dumitrascu OM ; Lamb J ; Lyden PD
  • J Cereb Blood Flow Metab 2016[Jul]; 36 (7 ): 1157-64 PMID27089911 show ga
  • Therapeutic hypothermia is the most potent neuroprotectant for experimental cerebral ischemia, illustrated in a 2007 meta-analysis published in this journal. To address recent therapeutic nihilism, we systematically reviewed recent experimental literature. Quality scoring showed considerable improvement in study design. Using several outcome measures in a variety of models and species, therapeutic hypothermia was protective compared with normothermia, with powerful and statistically significant normalized treatment effect sizes, in 60 papers comprising 216 comparisons. In the past 5 years, preclinical studies of ischemic stroke re-emphasize that therapeutic hypothermia is potently effective, justifying further development in larger human clinical trials.
  • |Animals [MESH]
  • |Brain Ischemia/complications/*therapy [MESH]
  • |Humans [MESH]
  • |Hypothermia, Induced/*methods [MESH]
  • |Stroke/etiology/*therapy [MESH]


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