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10.1016/j.ajpath.2016.02.022 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2016.02.022 C4929397!4929397!27338106     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 2016 ; 186 (7): 1712-23 Nephropedia Template TP {{tp|p=27338106|t=2016. Nuclear Factor?Erythroid-2?Related Factor 2 in Aging and Lung Fibrosis |pdf=|usr=}}{{27338106}} gab.com Text Nuclear Factor Erythroid-2 Related Factor 2 in Aging and Lung Fibrosis JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27338106 #FOAvip Aging and age-related diseases have been associated with elevated oxidative stress, which may be related to increased production of reactive species and/or a deficiency in antioxidant defenses. The nuclear factor-erythroid-2?related factor 2 (Nrf2)-mediated antioxidant response pathway maintains cellular reduction-oxidation homeostasis by inducing the transcription of an array of cytoprotective genes. However, there is evidence of impaired Nrf2 response in aging contributing to age-related fibrotic diseases. Herein, we review mechanisms for the dysregulation of Nrf2 signaling in aging. This understanding will pave the way for the design of novel therapeutic strategies that restore Nrf2 signaling to reestablish cellular homeostasis in aging and age-related fibrotic diseases. Twit Text FOAVip Nuclear Factor Erythroid-2 Related Factor 2 in Aging and Lung Fibrosis ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27338106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27338106 #FOAvip English Wikipedia <ref>{{Cite pmid|27338106}}</ref> Nuclear Factor?Erythroid-2?Related Factor 2 in Aging and Lung Fibrosis #MMPMID27338106 Swamy SM; Rajasekaran NS; Thannickal VJ Am J Pathol 2016[Jul]; 186 (7): 1712-23 PMID27338106show ga Aging and age-related diseases have been associated with elevated oxidative stress, which may be related to increased production of reactive species and/or a deficiency in antioxidant defenses. The nuclear factor-erythroid-2?related factor 2 (Nrf2)-mediated antioxidant response pathway maintains cellular reduction-oxidation homeostasis by inducing the transcription of an array of cytoprotective genes. However, there is evidence of impaired Nrf2 response in aging contributing to age-related fibrotic diseases. Herein, we review mechanisms for the dysregulation of Nrf2 signaling in aging. This understanding will pave the way for the design of novel therapeutic strategies that restore Nrf2 signaling to reestablish cellular homeostasis in aging and age-related fibrotic diseases. äNuclear Factor?Erythroid-2?Related Factor 2 in Aging and Lung Fibrosis(epmc).pdf DeepDyve Pubget Overpricing